Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.

Two new benzyl derivatives were isolated from ethyl acetate fraction of wild strawberry, Fragaria vesca var. nubicola Lindl. ex Hook.f. The structures of these compounds were elucidated to be 5-(4-hydroxy-3-methoxyphenethyl)-7-methoxy-2H-chromen-3-ol (1) and 5-(4-hydroxy-3-methoxyphenethyl)-4,7-dime...

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Autores principales: Naz, Sadia, Farooq, Umar, Khan, Ajmal, Khan, Haroon, Karim, Nasiara, Sarwar, Rizwana, Hussain, Javid, Rauf, Abdur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524885/
https://www.ncbi.nlm.nih.gov/pubmed/28790915
http://dx.doi.org/10.3389/fphar.2017.00469
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author Naz, Sadia
Farooq, Umar
Khan, Ajmal
Khan, Haroon
Karim, Nasiara
Sarwar, Rizwana
Hussain, Javid
Rauf, Abdur
author_facet Naz, Sadia
Farooq, Umar
Khan, Ajmal
Khan, Haroon
Karim, Nasiara
Sarwar, Rizwana
Hussain, Javid
Rauf, Abdur
author_sort Naz, Sadia
collection PubMed
description Two new benzyl derivatives were isolated from ethyl acetate fraction of wild strawberry, Fragaria vesca var. nubicola Lindl. ex Hook.f. The structures of these compounds were elucidated to be 5-(4-hydroxy-3-methoxyphenethyl)-7-methoxy-2H-chromen-3-ol (1) and 5-(4-hydroxy-3-methoxyphenethyl)-4,7-dimethoxy-2H-chromen-3-ol (2) based on spectroscopic data through IR, UV, (1)H-NMR, (13)C-NMR along with two dimensional (2D) techniques HMBC, HMQC, and COSY. Both compounds 1 and 2 were studied in tail suspension and forced swim tests for antidepressant like effects. A significant dose dependent antidepressant like effect was observed by causing spontaneous anti-immobility at various test doses upon intraperitoneal administration.
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spelling pubmed-55248852017-08-08 Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f. Naz, Sadia Farooq, Umar Khan, Ajmal Khan, Haroon Karim, Nasiara Sarwar, Rizwana Hussain, Javid Rauf, Abdur Front Pharmacol Pharmacology Two new benzyl derivatives were isolated from ethyl acetate fraction of wild strawberry, Fragaria vesca var. nubicola Lindl. ex Hook.f. The structures of these compounds were elucidated to be 5-(4-hydroxy-3-methoxyphenethyl)-7-methoxy-2H-chromen-3-ol (1) and 5-(4-hydroxy-3-methoxyphenethyl)-4,7-dimethoxy-2H-chromen-3-ol (2) based on spectroscopic data through IR, UV, (1)H-NMR, (13)C-NMR along with two dimensional (2D) techniques HMBC, HMQC, and COSY. Both compounds 1 and 2 were studied in tail suspension and forced swim tests for antidepressant like effects. A significant dose dependent antidepressant like effect was observed by causing spontaneous anti-immobility at various test doses upon intraperitoneal administration. Frontiers Media S.A. 2017-07-25 /pmc/articles/PMC5524885/ /pubmed/28790915 http://dx.doi.org/10.3389/fphar.2017.00469 Text en Copyright © 2017 Naz, Farooq, Khan, Khan, Karim, Sarwar, Hussain and Rauf. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Naz, Sadia
Farooq, Umar
Khan, Ajmal
Khan, Haroon
Karim, Nasiara
Sarwar, Rizwana
Hussain, Javid
Rauf, Abdur
Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.
title Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.
title_full Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.
title_fullStr Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.
title_full_unstemmed Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.
title_short Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.
title_sort antidepressent effect of two new benzyl derivatives from wild strawberry fragaria vesca var. nubicola lindl. ex hook.f.
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524885/
https://www.ncbi.nlm.nih.gov/pubmed/28790915
http://dx.doi.org/10.3389/fphar.2017.00469
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