In Vivo Sub-chronic Treatment with Dichlorvos in Young Rats Promotes Synaptic Plasticity and Learning by a Mechanism that Involves Acylpeptide Hydrolase Instead of Acetylcholinesterase Inhibition. Correlation with Endogenous β-Amyloid Levels

Acylpeptide hydrolase (APEH) is a serine hydrolase that displays two catalytic activities, acting both as an exopeptidase toward short N-acylated peptides and as an endopeptidase toward oxidized peptides or proteins. It has been demonstrated that this enzyme can degrade monomers, dimers, and trimers...

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Detalles Bibliográficos
Autores principales: García-Rojo, Gonzalo, Gámiz, Fernando, Ampuero, Estíbaliz, Rojas-Espina, Daniel, Sandoval, Rodrigo, Rozas, Carlos, Morales, Bernardo, Wyneken, Ursula, Pancetti, Floria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524899/
https://www.ncbi.nlm.nih.gov/pubmed/28790916
http://dx.doi.org/10.3389/fphar.2017.00483

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