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Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage
Diseases and toxins may lead to death of active liver tissue, resulting in a loss of total clearance capacity at the whole-body level. However, it remains difficult to study, whether the loss of metabolizing tissue is sufficient to explain loss of metabolic capacity of the liver or whether the survi...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524914/ https://www.ncbi.nlm.nih.gov/pubmed/28740200 http://dx.doi.org/10.1038/s41598-017-04574-z |