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Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease

Pain is a distressing symptom of Parkinson disease (PD). We aim to determine whether the genetic variants of chronic pain-related genes contribute to pain in PD patients. We included 418 PD patients and evaluated pain severity on King’s PD pain scale. We genotyped rs6267, rs6269, rs4633, rs4818 and...

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Autores principales: Lin, Chin-Hsien, Chaudhuri, K. Ray, Fan, Jun-Yu, Ko, Chia-I., Rizos, Alexandra, Chang, Chia-Wen, Lin, Han-I., Wu, Yih-Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524945/
https://www.ncbi.nlm.nih.gov/pubmed/28740224
http://dx.doi.org/10.1038/s41598-017-06782-z
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author Lin, Chin-Hsien
Chaudhuri, K. Ray
Fan, Jun-Yu
Ko, Chia-I.
Rizos, Alexandra
Chang, Chia-Wen
Lin, Han-I.
Wu, Yih-Ru
author_facet Lin, Chin-Hsien
Chaudhuri, K. Ray
Fan, Jun-Yu
Ko, Chia-I.
Rizos, Alexandra
Chang, Chia-Wen
Lin, Han-I.
Wu, Yih-Ru
author_sort Lin, Chin-Hsien
collection PubMed
description Pain is a distressing symptom of Parkinson disease (PD). We aim to determine whether the genetic variants of chronic pain-related genes contribute to pain in PD patients. We included 418 PD patients and evaluated pain severity on King’s PD pain scale. We genotyped rs6267, rs6269, rs4633, rs4818 and rs4680 of COMT, rs6746030 of SCN9A, and rs1799971 of OPRM1. In total, 193 participants (46.2%) experienced pain. Compared to pain-free PD patients, PD patients with pain had an earlier age of onset, longer disease duration, and higher depression and motor severity (P < 0.01). The frequencies of COMT rs4680 “A” allele were higher in PD patients with pain than those without pain (46.1% vs. 31.1%, P < 0.01). Pain severity was significantly associated with disease duration (P = 0.02), and COMT rs6267 T allele (P < 0.01). We stratified PD by status of depression and the association between COMT rs6267 “GT” genotype and pain severity remained significant (P < 0.01). Furthermore, pain severity was significantly higher in participants having COMT rs4680 “GG” and “GA” genpotypes than those having “AA” genotype (P = 0.04). We concluded that depression and COMT rs4680 “GG” and “GA” genotypes and COMT rs6267 “GT” genotype contribute to pain in PD patients.
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spelling pubmed-55249452017-07-26 Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease Lin, Chin-Hsien Chaudhuri, K. Ray Fan, Jun-Yu Ko, Chia-I. Rizos, Alexandra Chang, Chia-Wen Lin, Han-I. Wu, Yih-Ru Sci Rep Article Pain is a distressing symptom of Parkinson disease (PD). We aim to determine whether the genetic variants of chronic pain-related genes contribute to pain in PD patients. We included 418 PD patients and evaluated pain severity on King’s PD pain scale. We genotyped rs6267, rs6269, rs4633, rs4818 and rs4680 of COMT, rs6746030 of SCN9A, and rs1799971 of OPRM1. In total, 193 participants (46.2%) experienced pain. Compared to pain-free PD patients, PD patients with pain had an earlier age of onset, longer disease duration, and higher depression and motor severity (P < 0.01). The frequencies of COMT rs4680 “A” allele were higher in PD patients with pain than those without pain (46.1% vs. 31.1%, P < 0.01). Pain severity was significantly associated with disease duration (P = 0.02), and COMT rs6267 T allele (P < 0.01). We stratified PD by status of depression and the association between COMT rs6267 “GT” genotype and pain severity remained significant (P < 0.01). Furthermore, pain severity was significantly higher in participants having COMT rs4680 “GG” and “GA” genpotypes than those having “AA” genotype (P = 0.04). We concluded that depression and COMT rs4680 “GG” and “GA” genotypes and COMT rs6267 “GT” genotype contribute to pain in PD patients. Nature Publishing Group UK 2017-07-24 /pmc/articles/PMC5524945/ /pubmed/28740224 http://dx.doi.org/10.1038/s41598-017-06782-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lin, Chin-Hsien
Chaudhuri, K. Ray
Fan, Jun-Yu
Ko, Chia-I.
Rizos, Alexandra
Chang, Chia-Wen
Lin, Han-I.
Wu, Yih-Ru
Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
title Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
title_full Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
title_fullStr Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
title_full_unstemmed Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
title_short Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease
title_sort depression and catechol-o-methyltransferase (comt) genetic variants are associated with pain in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524945/
https://www.ncbi.nlm.nih.gov/pubmed/28740224
http://dx.doi.org/10.1038/s41598-017-06782-z
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