Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma

Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the iden...

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Autores principales: Long, Wenyong, Yi, Yang, Chen, Shen, Cao, Qi, Zhao, Wei, Liu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525007/
https://www.ncbi.nlm.nih.gov/pubmed/28790919
http://dx.doi.org/10.3389/fphar.2017.00495
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author Long, Wenyong
Yi, Yang
Chen, Shen
Cao, Qi
Zhao, Wei
Liu, Qing
author_facet Long, Wenyong
Yi, Yang
Chen, Shen
Cao, Qi
Zhao, Wei
Liu, Qing
author_sort Long, Wenyong
collection PubMed
description Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effective treatments. This article reviews the conventional therapies and new potential therapeutic approaches for DIPG, including epigenetic therapy, immunotherapy, and the combination of stem cells with nanoparticle delivery systems.
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spelling pubmed-55250072017-08-08 Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma Long, Wenyong Yi, Yang Chen, Shen Cao, Qi Zhao, Wei Liu, Qing Front Pharmacol Pharmacology Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effective treatments. This article reviews the conventional therapies and new potential therapeutic approaches for DIPG, including epigenetic therapy, immunotherapy, and the combination of stem cells with nanoparticle delivery systems. Frontiers Media S.A. 2017-07-25 /pmc/articles/PMC5525007/ /pubmed/28790919 http://dx.doi.org/10.3389/fphar.2017.00495 Text en Copyright © 2017 Long, Yi, Chen, Cao, Zhao and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Long, Wenyong
Yi, Yang
Chen, Shen
Cao, Qi
Zhao, Wei
Liu, Qing
Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma
title Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma
title_full Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma
title_fullStr Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma
title_full_unstemmed Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma
title_short Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma
title_sort potential new therapies for pediatric diffuse intrinsic pontine glioma
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525007/
https://www.ncbi.nlm.nih.gov/pubmed/28790919
http://dx.doi.org/10.3389/fphar.2017.00495
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