Cargando…
Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been in...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Pathologists and the Korean Society for Cytopathology
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525035/ https://www.ncbi.nlm.nih.gov/pubmed/28592786 http://dx.doi.org/10.4132/jptm.2017.03.15 |
_version_ | 1783252574581817344 |
---|---|
author | Kim, Hyun-Jung Ko, Young Hyeh Kim, Ji Eun Lee, Seung-Sook Lee, Hyekyung Park, Gyeongsin Paik, Jin Ho Cha, Hee Jeong Choi, Yoo-Duk Han, Jae Ho Huh, Jooryung |
author_facet | Kim, Hyun-Jung Ko, Young Hyeh Kim, Ji Eun Lee, Seung-Sook Lee, Hyekyung Park, Gyeongsin Paik, Jin Ho Cha, Hee Jeong Choi, Yoo-Duk Han, Jae Ho Huh, Jooryung |
author_sort | Kim, Hyun-Jung |
collection | PubMed |
description | Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin’s lymphoma, and immune–deficiency associated LPDs (post-transplant and human immunodeficiency virus–associated LPDs). T-cell LPDs have been reported to be associated with EBV with a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphomas, extranodal nasal natural killer/T-cell lymphomas, and other rare histotypes. This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization. These LPD entities often pose diagnostic challenges, both clinically and pathologically, so it is important to understand their unique pathophysiology for correct diagnoses and optimal management. |
format | Online Article Text |
id | pubmed-5525035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Society of Pathologists and the Korean Society for Cytopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-55250352017-07-25 Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification Kim, Hyun-Jung Ko, Young Hyeh Kim, Ji Eun Lee, Seung-Sook Lee, Hyekyung Park, Gyeongsin Paik, Jin Ho Cha, Hee Jeong Choi, Yoo-Duk Han, Jae Ho Huh, Jooryung J Pathol Transl Med Review Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin’s lymphoma, and immune–deficiency associated LPDs (post-transplant and human immunodeficiency virus–associated LPDs). T-cell LPDs have been reported to be associated with EBV with a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphomas, extranodal nasal natural killer/T-cell lymphomas, and other rare histotypes. This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization. These LPD entities often pose diagnostic challenges, both clinically and pathologically, so it is important to understand their unique pathophysiology for correct diagnoses and optimal management. The Korean Society of Pathologists and the Korean Society for Cytopathology 2017-07 2017-06-05 /pmc/articles/PMC5525035/ /pubmed/28592786 http://dx.doi.org/10.4132/jptm.2017.03.15 Text en © 2017 The Korean Society of Pathologists/The Korean Society for Cytopathology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Kim, Hyun-Jung Ko, Young Hyeh Kim, Ji Eun Lee, Seung-Sook Lee, Hyekyung Park, Gyeongsin Paik, Jin Ho Cha, Hee Jeong Choi, Yoo-Duk Han, Jae Ho Huh, Jooryung Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification |
title | Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification |
title_full | Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification |
title_fullStr | Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification |
title_full_unstemmed | Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification |
title_short | Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification |
title_sort | epstein-barr virus–associated lymphoproliferative disorders: review and update on 2016 who classification |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525035/ https://www.ncbi.nlm.nih.gov/pubmed/28592786 http://dx.doi.org/10.4132/jptm.2017.03.15 |
work_keys_str_mv | AT kimhyunjung epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification AT koyounghyeh epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification AT kimjieun epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification AT leeseungsook epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification AT leehyekyung epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification AT parkgyeongsin epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification AT paikjinho epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification AT chaheejeong epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification AT choiyooduk epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification AT hanjaeho epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification AT huhjooryung epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification AT epsteinbarrvirusassociatedlymphoproliferativedisordersreviewandupdateon2016whoclassification |