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Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification

Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been in...

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Autores principales: Kim, Hyun-Jung, Ko, Young Hyeh, Kim, Ji Eun, Lee, Seung-Sook, Lee, Hyekyung, Park, Gyeongsin, Paik, Jin Ho, Cha, Hee Jeong, Choi, Yoo-Duk, Han, Jae Ho, Huh, Jooryung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and the Korean Society for Cytopathology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525035/
https://www.ncbi.nlm.nih.gov/pubmed/28592786
http://dx.doi.org/10.4132/jptm.2017.03.15
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author Kim, Hyun-Jung
Ko, Young Hyeh
Kim, Ji Eun
Lee, Seung-Sook
Lee, Hyekyung
Park, Gyeongsin
Paik, Jin Ho
Cha, Hee Jeong
Choi, Yoo-Duk
Han, Jae Ho
Huh, Jooryung
author_facet Kim, Hyun-Jung
Ko, Young Hyeh
Kim, Ji Eun
Lee, Seung-Sook
Lee, Hyekyung
Park, Gyeongsin
Paik, Jin Ho
Cha, Hee Jeong
Choi, Yoo-Duk
Han, Jae Ho
Huh, Jooryung
author_sort Kim, Hyun-Jung
collection PubMed
description Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin’s lymphoma, and immune–deficiency associated LPDs (post-transplant and human immunodeficiency virus–associated LPDs). T-cell LPDs have been reported to be associated with EBV with a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphomas, extranodal nasal natural killer/T-cell lymphomas, and other rare histotypes. This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization. These LPD entities often pose diagnostic challenges, both clinically and pathologically, so it is important to understand their unique pathophysiology for correct diagnoses and optimal management.
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spelling pubmed-55250352017-07-25 Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification Kim, Hyun-Jung Ko, Young Hyeh Kim, Ji Eun Lee, Seung-Sook Lee, Hyekyung Park, Gyeongsin Paik, Jin Ho Cha, Hee Jeong Choi, Yoo-Duk Han, Jae Ho Huh, Jooryung J Pathol Transl Med Review Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin’s lymphoma, and immune–deficiency associated LPDs (post-transplant and human immunodeficiency virus–associated LPDs). T-cell LPDs have been reported to be associated with EBV with a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphomas, extranodal nasal natural killer/T-cell lymphomas, and other rare histotypes. This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization. These LPD entities often pose diagnostic challenges, both clinically and pathologically, so it is important to understand their unique pathophysiology for correct diagnoses and optimal management. The Korean Society of Pathologists and the Korean Society for Cytopathology 2017-07 2017-06-05 /pmc/articles/PMC5525035/ /pubmed/28592786 http://dx.doi.org/10.4132/jptm.2017.03.15 Text en © 2017 The Korean Society of Pathologists/The Korean Society for Cytopathology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kim, Hyun-Jung
Ko, Young Hyeh
Kim, Ji Eun
Lee, Seung-Sook
Lee, Hyekyung
Park, Gyeongsin
Paik, Jin Ho
Cha, Hee Jeong
Choi, Yoo-Duk
Han, Jae Ho
Huh, Jooryung
Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
title Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
title_full Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
title_fullStr Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
title_full_unstemmed Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
title_short Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
title_sort epstein-barr virus–associated lymphoproliferative disorders: review and update on 2016 who classification
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525035/
https://www.ncbi.nlm.nih.gov/pubmed/28592786
http://dx.doi.org/10.4132/jptm.2017.03.15
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