Current Strategies in Cardiovascular Biomaterial Functionalization

Prevention of the coagulation cascade and platelet activation is the foremost demand for biomaterials in contact with blood. In this review we describe the underlying mechanisms of these processes and offer the current state of antithrombotic strategies. We give an overview of methods to prevent pro...

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Detalles Bibliográficos
Autores principales: Schopka, Simon, Schmid, Thomas, Schmid, Christof, Lehle, Karla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525184/
http://dx.doi.org/10.3390/ma3010638
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author Schopka, Simon
Schmid, Thomas
Schmid, Christof
Lehle, Karla
author_facet Schopka, Simon
Schmid, Thomas
Schmid, Christof
Lehle, Karla
author_sort Schopka, Simon
collection PubMed
description Prevention of the coagulation cascade and platelet activation is the foremost demand for biomaterials in contact with blood. In this review we describe the underlying mechanisms of these processes and offer the current state of antithrombotic strategies. We give an overview of methods to prevent protein and platelet adhesion, as well as techniques to immobilize biochemically active molecules on biomaterial surfaces. Finally, recent strategies in biofunctionalization by endothelial cell seeding as well as their possible clinical applications are discussed.
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spelling pubmed-55251842017-07-28 Current Strategies in Cardiovascular Biomaterial Functionalization Schopka, Simon Schmid, Thomas Schmid, Christof Lehle, Karla Materials (Basel) Review Prevention of the coagulation cascade and platelet activation is the foremost demand for biomaterials in contact with blood. In this review we describe the underlying mechanisms of these processes and offer the current state of antithrombotic strategies. We give an overview of methods to prevent protein and platelet adhesion, as well as techniques to immobilize biochemically active molecules on biomaterial surfaces. Finally, recent strategies in biofunctionalization by endothelial cell seeding as well as their possible clinical applications are discussed. Molecular Diversity Preservation International 2010-01-22 /pmc/articles/PMC5525184/ http://dx.doi.org/10.3390/ma3010638 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Schopka, Simon
Schmid, Thomas
Schmid, Christof
Lehle, Karla
Current Strategies in Cardiovascular Biomaterial Functionalization
title Current Strategies in Cardiovascular Biomaterial Functionalization
title_full Current Strategies in Cardiovascular Biomaterial Functionalization
title_fullStr Current Strategies in Cardiovascular Biomaterial Functionalization
title_full_unstemmed Current Strategies in Cardiovascular Biomaterial Functionalization
title_short Current Strategies in Cardiovascular Biomaterial Functionalization
title_sort current strategies in cardiovascular biomaterial functionalization
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525184/
http://dx.doi.org/10.3390/ma3010638
work_keys_str_mv AT schopkasimon currentstrategiesincardiovascularbiomaterialfunctionalization
AT schmidthomas currentstrategiesincardiovascularbiomaterialfunctionalization
AT schmidchristof currentstrategiesincardiovascularbiomaterialfunctionalization
AT lehlekarla currentstrategiesincardiovascularbiomaterialfunctionalization

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