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Carotid plaque rather than intima-media thickness as a predictor of recurrent vascular events in patients with acute ischemic stroke
BACKGROUND: To investigate the impacts of carotid plaque and intima-media thickness (IMT) on future vascular events (VEs) in the patients with acute ischemic stroke. METHODS: A total of 479 consecutive Korean patients with acute ischemic stroke were divided into 2 groups according to development of...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525267/ https://www.ncbi.nlm.nih.gov/pubmed/28738808 http://dx.doi.org/10.1186/s12947-017-0110-y |
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author | Yoon, Hyun Ju Kim, Kye Hun Park, Hyukjin Cho, Jae Yeong Hong, Young Joon Park, Hyung Wook Kim, Ju Han Ahn, Youngkeun Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun |
author_facet | Yoon, Hyun Ju Kim, Kye Hun Park, Hyukjin Cho, Jae Yeong Hong, Young Joon Park, Hyung Wook Kim, Ju Han Ahn, Youngkeun Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun |
author_sort | Yoon, Hyun Ju |
collection | PubMed |
description | BACKGROUND: To investigate the impacts of carotid plaque and intima-media thickness (IMT) on future vascular events (VEs) in the patients with acute ischemic stroke. METHODS: A total of 479 consecutive Korean patients with acute ischemic stroke were divided into 2 groups according to development of VEs; VE group (65.4 ± 10.9 years) vs no VE group (62.8 ± 13.2 years). VEs were defined as the development of recurrent stroke, coronary events, peripheral arterial disease, and death. Clinical, laboratory, and imaging findings were compared between the groups. RESULTS: During 105.5 ± 29.0 months of follow up, VEs were developed in 142 patients (29.6%). In univariate analysis, VEs were significantly associated with age, gender, diabetes, renal function, lipid levels, left ventricular function, carotid plaque or IMT. In multivariate analysis, the presence of carotid plaque, diabetes, renal function and male gender were independent predictors of future VEs in the patients with ischemic stroke, but carotid IMT was not a predictor of future VEs. Event free survival was significantly lower in patients with carotid plaque than without carotid plaque on Kaplan-Meier analysis (log rank p < 0.001). CONCLUSION: The present study demonstrated that diabetes, impaired renal function, male gender, and the presence of carotid plaque rather than IMT were independent predictors of future VEs in Korean patients with acute ischemic stroke. Active medical management and careful monitoring for the development of recurrent VEs are strongly recommended in patients with acute ischemic stroke and carotid plaque. |
format | Online Article Text |
id | pubmed-5525267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-55252672017-07-26 Carotid plaque rather than intima-media thickness as a predictor of recurrent vascular events in patients with acute ischemic stroke Yoon, Hyun Ju Kim, Kye Hun Park, Hyukjin Cho, Jae Yeong Hong, Young Joon Park, Hyung Wook Kim, Ju Han Ahn, Youngkeun Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun Cardiovasc Ultrasound Research BACKGROUND: To investigate the impacts of carotid plaque and intima-media thickness (IMT) on future vascular events (VEs) in the patients with acute ischemic stroke. METHODS: A total of 479 consecutive Korean patients with acute ischemic stroke were divided into 2 groups according to development of VEs; VE group (65.4 ± 10.9 years) vs no VE group (62.8 ± 13.2 years). VEs were defined as the development of recurrent stroke, coronary events, peripheral arterial disease, and death. Clinical, laboratory, and imaging findings were compared between the groups. RESULTS: During 105.5 ± 29.0 months of follow up, VEs were developed in 142 patients (29.6%). In univariate analysis, VEs were significantly associated with age, gender, diabetes, renal function, lipid levels, left ventricular function, carotid plaque or IMT. In multivariate analysis, the presence of carotid plaque, diabetes, renal function and male gender were independent predictors of future VEs in the patients with ischemic stroke, but carotid IMT was not a predictor of future VEs. Event free survival was significantly lower in patients with carotid plaque than without carotid plaque on Kaplan-Meier analysis (log rank p < 0.001). CONCLUSION: The present study demonstrated that diabetes, impaired renal function, male gender, and the presence of carotid plaque rather than IMT were independent predictors of future VEs in Korean patients with acute ischemic stroke. Active medical management and careful monitoring for the development of recurrent VEs are strongly recommended in patients with acute ischemic stroke and carotid plaque. BioMed Central 2017-07-24 /pmc/articles/PMC5525267/ /pubmed/28738808 http://dx.doi.org/10.1186/s12947-017-0110-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Yoon, Hyun Ju Kim, Kye Hun Park, Hyukjin Cho, Jae Yeong Hong, Young Joon Park, Hyung Wook Kim, Ju Han Ahn, Youngkeun Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun Carotid plaque rather than intima-media thickness as a predictor of recurrent vascular events in patients with acute ischemic stroke |
title | Carotid plaque rather than intima-media thickness as a predictor of recurrent vascular events in patients with acute ischemic stroke |
title_full | Carotid plaque rather than intima-media thickness as a predictor of recurrent vascular events in patients with acute ischemic stroke |
title_fullStr | Carotid plaque rather than intima-media thickness as a predictor of recurrent vascular events in patients with acute ischemic stroke |
title_full_unstemmed | Carotid plaque rather than intima-media thickness as a predictor of recurrent vascular events in patients with acute ischemic stroke |
title_short | Carotid plaque rather than intima-media thickness as a predictor of recurrent vascular events in patients with acute ischemic stroke |
title_sort | carotid plaque rather than intima-media thickness as a predictor of recurrent vascular events in patients with acute ischemic stroke |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525267/ https://www.ncbi.nlm.nih.gov/pubmed/28738808 http://dx.doi.org/10.1186/s12947-017-0110-y |
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