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Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease
Recent studies have identified links between host genetic variants and microbial recognition of the microbiome. Defects in host–microbiome interactions in individuals harboring inflammatory bowel disease risk alleles may result in imbalances of the microbial community, impaired pathogen clearance, a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525272/ https://www.ncbi.nlm.nih.gov/pubmed/28738853 http://dx.doi.org/10.1186/s13073-017-0459-4 |
| _version_ | 1783252614082723840 |
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| author | Chu, Hiutung |
| author_facet | Chu, Hiutung |
| author_sort | Chu, Hiutung |
| collection | PubMed |
| description | Recent studies have identified links between host genetic variants and microbial recognition of the microbiome. Defects in host–microbiome interactions in individuals harboring inflammatory bowel disease risk alleles may result in imbalances of the microbial community, impaired pathogen clearance, and failure to sense beneficial commensal microbes. These findings highlight the importance of maintaining bi-directional communication at the mucosal interface during intestinal homeostasis. |
| format | Online Article Text |
| id | pubmed-5525272 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-55252722017-07-26 Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease Chu, Hiutung Genome Med Comment Recent studies have identified links between host genetic variants and microbial recognition of the microbiome. Defects in host–microbiome interactions in individuals harboring inflammatory bowel disease risk alleles may result in imbalances of the microbial community, impaired pathogen clearance, and failure to sense beneficial commensal microbes. These findings highlight the importance of maintaining bi-directional communication at the mucosal interface during intestinal homeostasis. BioMed Central 2017-07-24 /pmc/articles/PMC5525272/ /pubmed/28738853 http://dx.doi.org/10.1186/s13073-017-0459-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Comment Chu, Hiutung Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| title | Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| title_full | Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| title_fullStr | Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| title_full_unstemmed | Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| title_short | Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| title_sort | host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease |
| topic | Comment |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525272/ https://www.ncbi.nlm.nih.gov/pubmed/28738853 http://dx.doi.org/10.1186/s13073-017-0459-4 |
| work_keys_str_mv | AT chuhiutung hostgenemicrobiomeinteractionsmolecularmechanismsininflammatoryboweldisease |