The Role of Interferons in Inflammation and Inflammasome Activation

Inflammation is an essential physiological process, which enables survival during infection and maintains tissue homeostasis. Interferons (IFNs) and pro- and anti-inflammatory cytokines are crucial for appropriate response to pathogens, damaged cells, or irritants in inflammatory response. The infla...

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Detalles Bibliográficos
Autor principal: Kopitar-Jerala, Nataša
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525294/
https://www.ncbi.nlm.nih.gov/pubmed/28791024
http://dx.doi.org/10.3389/fimmu.2017.00873
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author Kopitar-Jerala, Nataša
author_facet Kopitar-Jerala, Nataša
author_sort Kopitar-Jerala, Nataša
collection PubMed
description Inflammation is an essential physiological process, which enables survival during infection and maintains tissue homeostasis. Interferons (IFNs) and pro- and anti-inflammatory cytokines are crucial for appropriate response to pathogens, damaged cells, or irritants in inflammatory response. The inflammasom is multiprotein complex, which initiates cleavage of pro-inflammatory cytokines IL-1β and IL-18 into active forms. In addition, inflammasomes initiate pyroptotic cell death. In the present review, I summarize and analyze recent findings regarding the cross talk of IFNs and inflammasomes.
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spelling pubmed-55252942017-08-08 The Role of Interferons in Inflammation and Inflammasome Activation Kopitar-Jerala, Nataša Front Immunol Immunology Inflammation is an essential physiological process, which enables survival during infection and maintains tissue homeostasis. Interferons (IFNs) and pro- and anti-inflammatory cytokines are crucial for appropriate response to pathogens, damaged cells, or irritants in inflammatory response. The inflammasom is multiprotein complex, which initiates cleavage of pro-inflammatory cytokines IL-1β and IL-18 into active forms. In addition, inflammasomes initiate pyroptotic cell death. In the present review, I summarize and analyze recent findings regarding the cross talk of IFNs and inflammasomes. Frontiers Media S.A. 2017-07-25 /pmc/articles/PMC5525294/ /pubmed/28791024 http://dx.doi.org/10.3389/fimmu.2017.00873 Text en Copyright © 2017 Kopitar-Jerala. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kopitar-Jerala, Nataša
The Role of Interferons in Inflammation and Inflammasome Activation
title The Role of Interferons in Inflammation and Inflammasome Activation
title_full The Role of Interferons in Inflammation and Inflammasome Activation
title_fullStr The Role of Interferons in Inflammation and Inflammasome Activation
title_full_unstemmed The Role of Interferons in Inflammation and Inflammasome Activation
title_short The Role of Interferons in Inflammation and Inflammasome Activation
title_sort role of interferons in inflammation and inflammasome activation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525294/
https://www.ncbi.nlm.nih.gov/pubmed/28791024
http://dx.doi.org/10.3389/fimmu.2017.00873
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