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Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome

BACKGROUND: We and others have observed that young girls predisposed to polycystic ovary syndrome (PCOS) display defective insulin sensitivity, beta-cell function and non-esterified fatty acids (NEFA) suppressibility during early pubertal years, compared to controls. Our objective is to assess wheth...

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Autores principales: Harnois-Leblanc, Soren, Trottier, Andréanne, Leblanc, Samuel, Battista, Marie-Claude, Geller, David H., Baillargeon, Jean-Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525344/
https://www.ncbi.nlm.nih.gov/pubmed/28738839
http://dx.doi.org/10.1186/s12958-017-0275-0
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author Harnois-Leblanc, Soren
Trottier, Andréanne
Leblanc, Samuel
Battista, Marie-Claude
Geller, David H.
Baillargeon, Jean-Patrice
author_facet Harnois-Leblanc, Soren
Trottier, Andréanne
Leblanc, Samuel
Battista, Marie-Claude
Geller, David H.
Baillargeon, Jean-Patrice
author_sort Harnois-Leblanc, Soren
collection PubMed
description BACKGROUND: We and others have observed that young girls predisposed to polycystic ovary syndrome (PCOS) display defective insulin sensitivity, beta-cell function and non-esterified fatty acids (NEFA) suppressibility during early pubertal years, compared to controls. Our objective is to assess whether these differences in glucose and NEFA metabolisms persist after 5 years in late/post-puberty. METHODS: We conducted a prospective cohort study between 2007 and 2015 with 4–6 years of follow-up in an academic institution research center. We compared 8 daughters and sisters of PCOS women (PCOSr) to 8 age-matched girls unrelated to PCOS (±1.5 years). Girls were assessed initially at 8–14 years old and re-assessed after a median follow-up of 5.4 years, at 13–21 years old. Our main measures were a frequently sampled intravenous glucose tolerance test (FSivGTT)-derived insulin sensitivity (IS) and beta-cell function (disposition index, DI(FSivGTT)); and indices of NEFA suppression during FSivGTT (log(n)-linear slope of NEFA and T(50) of NEFA suppression). RESULTS: At follow-up, both PCOSr and controls had similar results: IS = 3.2 vs 3.4 (p = 0.88), DI(FSivGTT) = 1926 vs 1380 (p = 0.44), log(n)-linear slope = −0.032 vs −0.032 (p = 0.88) and T(50)NEFA = 18.1 vs 20.8 min (p = 0.57). IS, DI(FSivGTT) and NEFA suppressibility were stable in PCOSr after 5 years, but decreased significantly in controls (all p < 0.05). CONCLUSIONS: Impaired metabolism observed during early puberty in girls predisposed to PCOS remains stable after 5 years whereas control girls deteriorated their metabolic parameters. Therefore, both groups become comparable in late/post-puberty. Early puberty may thus represent a window during which metabolic alterations are transiently apparent in girls at risk of PCOS.
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spelling pubmed-55253442017-07-26 Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome Harnois-Leblanc, Soren Trottier, Andréanne Leblanc, Samuel Battista, Marie-Claude Geller, David H. Baillargeon, Jean-Patrice Reprod Biol Endocrinol Research BACKGROUND: We and others have observed that young girls predisposed to polycystic ovary syndrome (PCOS) display defective insulin sensitivity, beta-cell function and non-esterified fatty acids (NEFA) suppressibility during early pubertal years, compared to controls. Our objective is to assess whether these differences in glucose and NEFA metabolisms persist after 5 years in late/post-puberty. METHODS: We conducted a prospective cohort study between 2007 and 2015 with 4–6 years of follow-up in an academic institution research center. We compared 8 daughters and sisters of PCOS women (PCOSr) to 8 age-matched girls unrelated to PCOS (±1.5 years). Girls were assessed initially at 8–14 years old and re-assessed after a median follow-up of 5.4 years, at 13–21 years old. Our main measures were a frequently sampled intravenous glucose tolerance test (FSivGTT)-derived insulin sensitivity (IS) and beta-cell function (disposition index, DI(FSivGTT)); and indices of NEFA suppression during FSivGTT (log(n)-linear slope of NEFA and T(50) of NEFA suppression). RESULTS: At follow-up, both PCOSr and controls had similar results: IS = 3.2 vs 3.4 (p = 0.88), DI(FSivGTT) = 1926 vs 1380 (p = 0.44), log(n)-linear slope = −0.032 vs −0.032 (p = 0.88) and T(50)NEFA = 18.1 vs 20.8 min (p = 0.57). IS, DI(FSivGTT) and NEFA suppressibility were stable in PCOSr after 5 years, but decreased significantly in controls (all p < 0.05). CONCLUSIONS: Impaired metabolism observed during early puberty in girls predisposed to PCOS remains stable after 5 years whereas control girls deteriorated their metabolic parameters. Therefore, both groups become comparable in late/post-puberty. Early puberty may thus represent a window during which metabolic alterations are transiently apparent in girls at risk of PCOS. BioMed Central 2017-07-24 /pmc/articles/PMC5525344/ /pubmed/28738839 http://dx.doi.org/10.1186/s12958-017-0275-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Harnois-Leblanc, Soren
Trottier, Andréanne
Leblanc, Samuel
Battista, Marie-Claude
Geller, David H.
Baillargeon, Jean-Patrice
Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome
title Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome
title_full Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome
title_fullStr Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome
title_full_unstemmed Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome
title_short Evolution of metabolic alterations 5 Years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome
title_sort evolution of metabolic alterations 5 years after early puberty in a cohort of girls predisposed to polycystic ovary syndrome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525344/
https://www.ncbi.nlm.nih.gov/pubmed/28738839
http://dx.doi.org/10.1186/s12958-017-0275-0
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