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Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity
The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,6′-dimycolate, or cord factor, and the mammal...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525440/ https://www.ncbi.nlm.nih.gov/pubmed/28791019 http://dx.doi.org/10.3389/fimmu.2017.00861 |
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author | Patin, Emmanuel C. Orr, Selinda Jane Schaible, Ulrich E. |
author_facet | Patin, Emmanuel C. Orr, Selinda Jane Schaible, Ulrich E. |
author_sort | Patin, Emmanuel C. |
collection | PubMed |
description | The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,6′-dimycolate, or cord factor, and the mammalian necrotic cell-derived alarmin histone deacetylase complex unit Sin3-associated protein 130. Upon engagement by its ligands, Mincle induces secretion of innate cytokines and other immune mediators modulating inflammation and immunity. Since its discovery more than 25 years ago, the understanding of Mincle’s immune function has made significant advances in recent years. In addition to mediating immune responses to infectious agents, Mincle has been linked to promote tumor progression, autoimmunity, and sterile inflammation; however, further studies are required to completely unravel the complex role of Mincle in these distinct host responses. In this review, we discuss recent findings on Mincle’s biology with an emphasis on its diverse functions in immunity. |
format | Online Article Text |
id | pubmed-5525440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55254402017-08-08 Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity Patin, Emmanuel C. Orr, Selinda Jane Schaible, Ulrich E. Front Immunol Immunology The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,6′-dimycolate, or cord factor, and the mammalian necrotic cell-derived alarmin histone deacetylase complex unit Sin3-associated protein 130. Upon engagement by its ligands, Mincle induces secretion of innate cytokines and other immune mediators modulating inflammation and immunity. Since its discovery more than 25 years ago, the understanding of Mincle’s immune function has made significant advances in recent years. In addition to mediating immune responses to infectious agents, Mincle has been linked to promote tumor progression, autoimmunity, and sterile inflammation; however, further studies are required to completely unravel the complex role of Mincle in these distinct host responses. In this review, we discuss recent findings on Mincle’s biology with an emphasis on its diverse functions in immunity. Frontiers Media S.A. 2017-07-25 /pmc/articles/PMC5525440/ /pubmed/28791019 http://dx.doi.org/10.3389/fimmu.2017.00861 Text en Copyright © 2017 Patin, Orr and Schaible. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Patin, Emmanuel C. Orr, Selinda Jane Schaible, Ulrich E. Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity |
title | Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity |
title_full | Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity |
title_fullStr | Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity |
title_full_unstemmed | Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity |
title_short | Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity |
title_sort | macrophage inducible c-type lectin as a multifunctional player in immunity |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525440/ https://www.ncbi.nlm.nih.gov/pubmed/28791019 http://dx.doi.org/10.3389/fimmu.2017.00861 |
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