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Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity

The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,6′-dimycolate, or cord factor, and the mammal...

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Autores principales: Patin, Emmanuel C., Orr, Selinda Jane, Schaible, Ulrich E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525440/
https://www.ncbi.nlm.nih.gov/pubmed/28791019
http://dx.doi.org/10.3389/fimmu.2017.00861
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author Patin, Emmanuel C.
Orr, Selinda Jane
Schaible, Ulrich E.
author_facet Patin, Emmanuel C.
Orr, Selinda Jane
Schaible, Ulrich E.
author_sort Patin, Emmanuel C.
collection PubMed
description The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,6′-dimycolate, or cord factor, and the mammalian necrotic cell-derived alarmin histone deacetylase complex unit Sin3-associated protein 130. Upon engagement by its ligands, Mincle induces secretion of innate cytokines and other immune mediators modulating inflammation and immunity. Since its discovery more than 25 years ago, the understanding of Mincle’s immune function has made significant advances in recent years. In addition to mediating immune responses to infectious agents, Mincle has been linked to promote tumor progression, autoimmunity, and sterile inflammation; however, further studies are required to completely unravel the complex role of Mincle in these distinct host responses. In this review, we discuss recent findings on Mincle’s biology with an emphasis on its diverse functions in immunity.
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spelling pubmed-55254402017-08-08 Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity Patin, Emmanuel C. Orr, Selinda Jane Schaible, Ulrich E. Front Immunol Immunology The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,6′-dimycolate, or cord factor, and the mammalian necrotic cell-derived alarmin histone deacetylase complex unit Sin3-associated protein 130. Upon engagement by its ligands, Mincle induces secretion of innate cytokines and other immune mediators modulating inflammation and immunity. Since its discovery more than 25 years ago, the understanding of Mincle’s immune function has made significant advances in recent years. In addition to mediating immune responses to infectious agents, Mincle has been linked to promote tumor progression, autoimmunity, and sterile inflammation; however, further studies are required to completely unravel the complex role of Mincle in these distinct host responses. In this review, we discuss recent findings on Mincle’s biology with an emphasis on its diverse functions in immunity. Frontiers Media S.A. 2017-07-25 /pmc/articles/PMC5525440/ /pubmed/28791019 http://dx.doi.org/10.3389/fimmu.2017.00861 Text en Copyright © 2017 Patin, Orr and Schaible. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Patin, Emmanuel C.
Orr, Selinda Jane
Schaible, Ulrich E.
Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity
title Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity
title_full Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity
title_fullStr Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity
title_full_unstemmed Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity
title_short Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity
title_sort macrophage inducible c-type lectin as a multifunctional player in immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525440/
https://www.ncbi.nlm.nih.gov/pubmed/28791019
http://dx.doi.org/10.3389/fimmu.2017.00861
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