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Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital

BACKGROUND: Septicemia is an important cause of neonatal morbidity and mortality. However, organized data on causative organisms and their resistant pattern are scanty from developing countries. The changing trend in causative organisms and their antibiotic resistance is yet to be documented in Indi...

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Autores principales: Roy, MP, Bhatt, M, Maurya, V, Arya, S, Gaind, R, Chellani, HK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525480/
https://www.ncbi.nlm.nih.gov/pubmed/28272077
http://dx.doi.org/10.4103/0022-3859.201425
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author Roy, MP
Bhatt, M
Maurya, V
Arya, S
Gaind, R
Chellani, HK
author_facet Roy, MP
Bhatt, M
Maurya, V
Arya, S
Gaind, R
Chellani, HK
author_sort Roy, MP
collection PubMed
description BACKGROUND: Septicemia is an important cause of neonatal morbidity and mortality. However, organized data on causative organisms and their resistant pattern are scanty from developing countries. The changing trend in causative organisms and their antibiotic resistance is yet to be documented in India. The present study examines the trends in bacterial profile and antibiotic resistance of the organisms causing sepsis in hospitalized neonates. MATERIALS AND METHODS: A retrospective laboratory-based analysis of blood cultures obtained from Neonatal Intensive Care Unit of a tertiary care hospital in New Delhi was done for the period of 1999–2014, divided into five phases. RESULTS: A total of 4700 isolates were considered. Over time, Gram-negative organisms have replaced Gram-positives as frequent isolates. Initially, there was predominance of Klebsiella pneumoniae, then of Staphylococcus aureus which recently has been changed with coagulase negative-Staphylococcus and Acinetobacter. Growing resistance against the first and second line of drugs has been noted, including methicillin-resistant S. aureus and vancomycin-resistant Enterococcus. CONCLUSION: The etiological profile of neonatal sepsis has changed tremendously in the past 15 years. High resistance against common drugs necessitates continued surveillance and review of empirical antibiotic policy for neonatal sepsis. These steps are important to effectively curtail the surge of further antibiotic resistance.
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spelling pubmed-55254802017-08-08 Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital Roy, MP Bhatt, M Maurya, V Arya, S Gaind, R Chellani, HK J Postgrad Med Original Article BACKGROUND: Septicemia is an important cause of neonatal morbidity and mortality. However, organized data on causative organisms and their resistant pattern are scanty from developing countries. The changing trend in causative organisms and their antibiotic resistance is yet to be documented in India. The present study examines the trends in bacterial profile and antibiotic resistance of the organisms causing sepsis in hospitalized neonates. MATERIALS AND METHODS: A retrospective laboratory-based analysis of blood cultures obtained from Neonatal Intensive Care Unit of a tertiary care hospital in New Delhi was done for the period of 1999–2014, divided into five phases. RESULTS: A total of 4700 isolates were considered. Over time, Gram-negative organisms have replaced Gram-positives as frequent isolates. Initially, there was predominance of Klebsiella pneumoniae, then of Staphylococcus aureus which recently has been changed with coagulase negative-Staphylococcus and Acinetobacter. Growing resistance against the first and second line of drugs has been noted, including methicillin-resistant S. aureus and vancomycin-resistant Enterococcus. CONCLUSION: The etiological profile of neonatal sepsis has changed tremendously in the past 15 years. High resistance against common drugs necessitates continued surveillance and review of empirical antibiotic policy for neonatal sepsis. These steps are important to effectively curtail the surge of further antibiotic resistance. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5525480/ /pubmed/28272077 http://dx.doi.org/10.4103/0022-3859.201425 Text en Copyright: © 2017 Journal of Postgraduate Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Roy, MP
Bhatt, M
Maurya, V
Arya, S
Gaind, R
Chellani, HK
Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital
title Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital
title_full Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital
title_fullStr Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital
title_full_unstemmed Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital
title_short Changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital
title_sort changing trend in bacterial etiology and antibiotic resistance in sepsis of intramural neonates at a tertiary care hospital
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525480/
https://www.ncbi.nlm.nih.gov/pubmed/28272077
http://dx.doi.org/10.4103/0022-3859.201425
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