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High-Yield Synthesis of Monomeric LMWP(CPP)-siRNA Covalent Conjugate for Effective Cytosolic Delivery of siRNA

Because of the unparalleled efficiency and universal utility in treating a variety of disease types, siRNA agents have evolved as the future drug-of-choice. Yet, the inability of the polyanionic siRNA macromolecules to cross the cell membrane remains as the bottleneck of possible clinical applicatio...

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Detalles Bibliográficos
Autores principales:	Ye, Junxiao, Liu, Ergang, Gong, Junbo, Wang, Jianxin, Huang, Yongzhuo, He, Huining, Yang, Victor C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525752/ https://www.ncbi.nlm.nih.gov/pubmed/28744330 http://dx.doi.org/10.7150/thno.19863

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