Cargando…

2D-STI combined with gated (99)Tc(m)-MIBI MPI for the diagnosis of myocardial ischemia in hypercholesterolemia patients

This study aimed to investigate the reliability of ultrasound two-dimensional speckle tracking imaging (2D-STI) for the evaluation of myocardial ischemia in familial hypercholesterolemia (FH) patients. We recruited 28 patients clinically diagnosed with homozygous familial hypercholesterolemia (HoFH)...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Yi, Zhang, Rui-Fang, Liu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526078/
https://www.ncbi.nlm.nih.gov/pubmed/28810550
http://dx.doi.org/10.3892/etm.2017.4602
_version_ 1783252757561475072
author Song, Yi
Zhang, Rui-Fang
Liu, Yu
author_facet Song, Yi
Zhang, Rui-Fang
Liu, Yu
author_sort Song, Yi
collection PubMed
description This study aimed to investigate the reliability of ultrasound two-dimensional speckle tracking imaging (2D-STI) for the evaluation of myocardial ischemia in familial hypercholesterolemia (FH) patients. We recruited 28 patients clinically diagnosed with homozygous familial hypercholesterolemia (HoFH) and subjected them to 2D-STI, gated transthoracic Doppler echocardiography (TTDE), and (99)Tc(m)-methoxyisobutylisonitrile myocardial perfusion imaging ((99)Tc(m)-MIBI MPI). The sensitivity, specificity and diagnostic accordance rate of TTDE and 2D-STI for myocardial ischemia in HoFH patients were compared with the (99)Tc(m)-MIBI scores. According to the diagnosis of ischemia in the three main coronary arteries (LAD, LCX, and RCA) by MPI, patients were further divided into different groups for comparing segmental strain by 2D-STI. The total correlation between TTDE and (99)Tc(m)-MIBI MPI for evaluation of myocardial ischemia was r=0.483 and between 2D-STI and (99)Tc(m)-MIBI MPI was 0.786. The total correlation index for ejection fraction (EF) between TTDE and (99)Tc(m)-MIBI MPI was r=0.606 and for 2D-STI and (99)Tc(m)-MIBI MPI was r=0.919. TTDE indicated that differences among LVDd, LVDs, IVS, LVPW, AO Vmax, PG, E/e', and DT were statistically significant. STI indicated that the total strain of the ischemia group was lower than that of the non-ischemia group. The total systolic strain and total early diastolic strain of the ischemia group were lower than that of the non-ischemia group. TTDE can be used for primary observation and evaluation of ventricular wall ischemia for HoFH patients. Ultrasound 2D-STI is better than TTDE in the evaluation of myocardial ischemia in HoFH patients. Ultrasound 2D-STI shows the same effectiveness as (99)Tc(m)-MIBI MPI for the detection of myocardial ischemia, serving as good tool for prognosis and treatment evaluation in HoFH patients.
format Online
Article
Text
id pubmed-5526078
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-55260782017-08-11 2D-STI combined with gated (99)Tc(m)-MIBI MPI for the diagnosis of myocardial ischemia in hypercholesterolemia patients Song, Yi Zhang, Rui-Fang Liu, Yu Exp Ther Med Articles This study aimed to investigate the reliability of ultrasound two-dimensional speckle tracking imaging (2D-STI) for the evaluation of myocardial ischemia in familial hypercholesterolemia (FH) patients. We recruited 28 patients clinically diagnosed with homozygous familial hypercholesterolemia (HoFH) and subjected them to 2D-STI, gated transthoracic Doppler echocardiography (TTDE), and (99)Tc(m)-methoxyisobutylisonitrile myocardial perfusion imaging ((99)Tc(m)-MIBI MPI). The sensitivity, specificity and diagnostic accordance rate of TTDE and 2D-STI for myocardial ischemia in HoFH patients were compared with the (99)Tc(m)-MIBI scores. According to the diagnosis of ischemia in the three main coronary arteries (LAD, LCX, and RCA) by MPI, patients were further divided into different groups for comparing segmental strain by 2D-STI. The total correlation between TTDE and (99)Tc(m)-MIBI MPI for evaluation of myocardial ischemia was r=0.483 and between 2D-STI and (99)Tc(m)-MIBI MPI was 0.786. The total correlation index for ejection fraction (EF) between TTDE and (99)Tc(m)-MIBI MPI was r=0.606 and for 2D-STI and (99)Tc(m)-MIBI MPI was r=0.919. TTDE indicated that differences among LVDd, LVDs, IVS, LVPW, AO Vmax, PG, E/e', and DT were statistically significant. STI indicated that the total strain of the ischemia group was lower than that of the non-ischemia group. The total systolic strain and total early diastolic strain of the ischemia group were lower than that of the non-ischemia group. TTDE can be used for primary observation and evaluation of ventricular wall ischemia for HoFH patients. Ultrasound 2D-STI is better than TTDE in the evaluation of myocardial ischemia in HoFH patients. Ultrasound 2D-STI shows the same effectiveness as (99)Tc(m)-MIBI MPI for the detection of myocardial ischemia, serving as good tool for prognosis and treatment evaluation in HoFH patients. D.A. Spandidos 2017-08 2017-06-14 /pmc/articles/PMC5526078/ /pubmed/28810550 http://dx.doi.org/10.3892/etm.2017.4602 Text en Copyright: © Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Song, Yi
Zhang, Rui-Fang
Liu, Yu
2D-STI combined with gated (99)Tc(m)-MIBI MPI for the diagnosis of myocardial ischemia in hypercholesterolemia patients
title 2D-STI combined with gated (99)Tc(m)-MIBI MPI for the diagnosis of myocardial ischemia in hypercholesterolemia patients
title_full 2D-STI combined with gated (99)Tc(m)-MIBI MPI for the diagnosis of myocardial ischemia in hypercholesterolemia patients
title_fullStr 2D-STI combined with gated (99)Tc(m)-MIBI MPI for the diagnosis of myocardial ischemia in hypercholesterolemia patients
title_full_unstemmed 2D-STI combined with gated (99)Tc(m)-MIBI MPI for the diagnosis of myocardial ischemia in hypercholesterolemia patients
title_short 2D-STI combined with gated (99)Tc(m)-MIBI MPI for the diagnosis of myocardial ischemia in hypercholesterolemia patients
title_sort 2d-sti combined with gated (99)tc(m)-mibi mpi for the diagnosis of myocardial ischemia in hypercholesterolemia patients
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526078/
https://www.ncbi.nlm.nih.gov/pubmed/28810550
http://dx.doi.org/10.3892/etm.2017.4602
work_keys_str_mv AT songyi 2dsticombinedwithgated99tcmmibimpiforthediagnosisofmyocardialischemiainhypercholesterolemiapatients
AT zhangruifang 2dsticombinedwithgated99tcmmibimpiforthediagnosisofmyocardialischemiainhypercholesterolemiapatients
AT liuyu 2dsticombinedwithgated99tcmmibimpiforthediagnosisofmyocardialischemiainhypercholesterolemiapatients