Cargando…

The lysosomal protein cathepsin L is a progranulin protease

Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has been shown to regulate brain PGRN levels, and complete deficiency of PGRN is a direct caus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Chris W., Stankowski, Jeannette N., Chew, Jeannie, Cook, Casey N., Lam, Ying-Wai, Almeida, Sandra, Carlomagno, Yari, Lau, Kwok-Fai, Prudencio, Mercedes, Gao, Fen-Biao, Bogyo, Matthew, Dickson, Dennis W., Petrucelli, Leonard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526245/ https://www.ncbi.nlm.nih.gov/pubmed/28743268 http://dx.doi.org/10.1186/s13024-017-0196-6

Ejemplares similares

Acetylation: a new key to unlock tau’s role in neurodegeneration
por: Cook, Casey, et al.
Publicado: (2014)

Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency
por: Lee, Wing C., et al.
Publicado: (2014)

Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal Protein
por: Anderson, Abigail, et al.
Publicado: (2023)

Lysosomal processing of progranulin
por: Zhou, Xiaolai, et al.
Publicado: (2017)

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration
por: Mohan, Swetha, et al.
Publicado: (2021)

The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease
por: Cocchiaro, Pasquale, et al.
Publicado: (2017)

The Key Role of Lysosomal Protease Cathepsins in Viral Infections
por: Scarcella, Melania, et al.
Publicado: (2022)

Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia
por: Telpoukhovskaia, Maria A., et al.
Publicado: (2020)

Progranulin takes an alternate route to lysosomes
por: Short, Ben
Publicado: (2015)

Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
por: Lösch, A., et al.
Publicado: (1996)

Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin
por: Du, Huan, et al.
Publicado: (2022)

Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S
por: Michiels, Thomas J. M., et al.
Publicado: (2020)

Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury
por: Cocchiaro, Pasquale, et al.
Publicado: (2016)

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
por: Zhou, Xiaolai, et al.
Publicado: (2015)

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency
por: Evers, Bret M., et al.
Publicado: (2017)

Delivering progranulin to neuronal lysosomes protects against excitotoxicity
por: Davis, Skylar E., et al.
Publicado: (2021)

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency
por: Frew, Jonathan, et al.
Publicado: (2020)

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy
por: Chew, Jeannie, et al.
Publicado: (2019)

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD
por: Wu, Yanwei, et al.
Publicado: (2021)

Progranulin regulates neuronal outgrowth independent of Sortilin
por: Gass, Jennifer, et al.
Publicado: (2012)

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
por: Beel, Sander, et al.
Publicado: (2017)

Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease
por: Fox, Christopher, et al.
Publicado: (2016)

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner
por: Wilkinson, Richard D.A., et al.
Publicado: (2015)

The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle‐down characterization of antibodies
por: Čaval, Tomislav, et al.
Publicado: (2021)

A two-trick pony: lysosomal protease cathepsin B possesses surprising ligase activity
por: Lambeth, Tyler R., et al.
Publicado: (2021)

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress
por: Zhang, Yong-Jie, et al.
Publicado: (2014)

Progranulin axis and recent developments in frontotemporal lobar degeneration
por: Nicholson, Alexandra M, et al.
Publicado: (2012)

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
por: Zhou, Xiaolai, et al.
Publicado: (2017)

Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons
por: Hasan, Saadia, et al.
Publicado: (2023)

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
por: Hasan, Saadia, et al.
Publicado: (2023)

Progranulin in frontotemporal lobar degeneration and neuroinflammation
por: Ahmed, Zeshan, et al.
Publicado: (2007)

Targeting lysosomal cysteine protease cathepsin S reveals immunomodulatory therapeutic strategy for oxaliplatin-induced peripheral neuropathy
por: Chen, Szu-Jung, et al.
Publicado: (2021)

Low‐level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus
por: Reinheckel, Thomas, et al.
Publicado: (2022)

Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes
por: Jian, Jinlong, et al.
Publicado: (2017)

Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway
por: Dong, Tingting, et al.
Publicado: (2021)

Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
por: Gillett, Drew A., et al.
Publicado: (2023)

Tau exhibits unique seeding properties in globular glial tauopathy
por: Chung, Dah-eun Chloe, et al.
Publicado: (2019)

Microglia in frontotemporal lobar degeneration with progranulin or C9ORF72 mutations
por: Sakae, Nobutaka, et al.
Publicado: (2019)

The AD tau core spontaneously self-assembles and recruits full-length tau to filaments
por: Carlomagno, Yari, et al.
Publicado: (2021)

Plasma PolyQ-ATXN3 Levels Associate With Cerebellar Degeneration and Behavioral Abnormalities in a New AAV-Based SCA3 Mouse Model
por: Jansen-West, Karen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t77184j5eqigkjk183jft2fck9