Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case report

BACKGROUND: The eosinophilic response to clozapine is well described in the literature, causing a variety of responses, from serositis to colitis. However, there are not case reports describing a clozapine-induced marked eosinophilia resulting in multiorgan dysfunction. CASE PRESENTATION: In this case report, we describe a 24 year old Caucasian male who presented with severe systemic eosinophilia resulting in eosinophilic GI tract infiltration, myocarditis, pericardial and pleural effusions with dramatic improvement following drug withdrawal. CONCLUSIONS: Clozapine associated eosinophilia should be suspected in the setting of eosinophilic infiltration of multiple organs.