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New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

The synthesis and molecular characterization of new isatin-based hydrazonoindolin-2-ones 4a-o and 7a-e are reported. The in vitro anti-proliferative potential of the synthesized compounds 4a-o and 7a-e was examined against HT-29 (colon), ZR-75 (breast) and A549 (lung) human cancer cell lines. Compou...

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Detalles Bibliográficos
Autores principales:	Attia, Mohamed I., Eldehna, Wagdy M., Afifi, Samar A., Keeton, Adam B., Piazza, Gary A., Abdel-Aziz, Hatem A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526551/ https://www.ncbi.nlm.nih.gov/pubmed/28742842 http://dx.doi.org/10.1371/journal.pone.0181241

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