Cargando…

Decreased Rhes mRNA levels in the brain of patients with Parkinson’s disease and MPTP-treated macaques

In rodent and human brains, the small GTP-binding protein Rhes is highly expressed in virtually all dopaminoceptive striatal GABAergic medium spiny neurons, as well as in large aspiny cholinergic interneurons, where it is thought to modulate dopamine-dependent signaling. Consistent with this knowled...

Descripción completa

Detalles Bibliográficos
Autores principales:	Napolitano, Francesco, Booth Warren, Emily, Migliarini, Sara, Punzo, Daniela, Errico, Francesco, Li, Qin, Thiolat, Marie-Laure, Vescovi, Angelo Luigi, Calabresi, Paolo, Bezard, Erwan, Morelli, Micaela, Konradi, Christine, Pasqualetti, Massimo, Usiello, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526584/ https://www.ncbi.nlm.nih.gov/pubmed/28742811 http://dx.doi.org/10.1371/journal.pone.0181677

Ejemplares similares

The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients
por: Nuzzo, Tommaso, et al.
Publicado: (2019)

Involvement of the Protein Ras Homolog Enriched in the Striatum, Rhes, in Dopaminergic Neurons’ Degeneration: Link to Parkinson’s Disease
por: Serra, Marcello, et al.
Publicado: (2021)

Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age
por: Costa, Giulia, et al.
Publicado: (2018)

Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion
por: Ghiglieri, Veronica, et al.
Publicado: (2015)

Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age
por: Costa, Giulia, et al.
Publicado: (2019)

The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses
por: Napolitano, Francesco, et al.
Publicado: (2019)

Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia
por: Subramaniam, Srinivasa, et al.
Publicado: (2011)

Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry
por: Pratelli, Marta, et al.
Publicado: (2017)

Gastrointestinal and metabolic function in the MPTP-treated macaque model of Parkinson's disease
por: Delamarre, Anna, et al.
Publicado: (2020)

Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model
por: Bourdenx, Mathieu, et al.
Publicado: (2017)

Exploration of sex differences in Rhes effects in dopamine mediated behaviors
por: Quintero, Gabriel C, et al.
Publicado: (2011)

Dopamine Transporter Binding Is Unaffected by L-DOPA Administration in Normal and MPTP-Treated Monkeys
por: Fernagut, Pierre-Olivier, et al.
Publicado: (2010)

Dysfunctional dopaminergic neurotransmission in asocial BTBR mice
por: Squillace, M, et al.
Publicado: (2014)

Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes
por: Thapliyal, Ashish, et al.
Publicado: (2014)

Rhes, a striatal-enriched protein, promotes mitophagy via Nix
por: Sharma, Manish, et al.
Publicado: (2019)

Global Rhes knockout in the Q175 Huntington’s disease mouse model
por: Heikkinen, Taneli, et al.
Publicado: (2021)

Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson’s disease primate model
por: Kaya, Ibrahim, et al.
Publicado: (2023)

Striatal Induction and Spread of the Huntington’s Disease Protein: A Novel Rhes Route
por: Subramaniam, Srinivasa
Publicado: (2022)

Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques
por: Dehay, Benjamin, et al.
Publicado: (2012)

Microdialysis in awake macaque monkeys for central nervous system pharmacokinetics
por: Thiollier, Thibaud, et al.
Publicado: (2018)

Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients
por: Nuzzo, Tommaso, et al.
Publicado: (2017)

Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
por: Arotcarena, Marie-Laure, et al.
Publicado: (2021)

Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain
por: Ramírez-Jarquín, Uri Nimrod, et al.
Publicado: (2022)

RasGRP1 is a causal factor in the development of l-DOPA–induced dyskinesia in Parkinson’s disease
por: Eshraghi, Mehdi, et al.
Publicado: (2020)

Behavioural Profiles in Captive-Bred Cynomolgus Macaques: Towards Monkey Models of Mental Disorders?
por: Camus, Sandrine M. J., et al.
Publicado: (2013)

Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
por: Arotcarena, Marie-Laure, et al.
Publicado: (2019)

Attenuation of Rhes Activity Significantly Delays the Appearance of Behavioral Symptoms in a Mouse Model of Huntington's Disease
por: Baiamonte, Brandon A., et al.
Publicado: (2013)

Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion
por: Sharma, Manish, et al.
Publicado: (2019)

Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model
por: Pan, Yongcheng, et al.
Publicado: (2023)

Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress
por: Maddaloni, Giacomo, et al.
Publicado: (2018)

D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans
por: Lombardo, Barbara, et al.
Publicado: (2022)

Depressive-like behavioral profiles in captive-bred single- and socially-housed rhesus and cynomolgus macaques: a species comparison
por: Camus, Sandrine M. J., et al.
Publicado: (2014)

Generation of Pet1(210)-Cre Transgenic Mouse Line Reveals Non-Serotonergic Expression Domains of Pet1 Both in CNS and Periphery
por: Pelosi, Barbara, et al.
Publicado: (2014)

Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin
por: Pelosi, Barbara, et al.
Publicado: (2015)

The MPTP Story
por: Langston, J. William
Publicado: (2017)

RGS9‐2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models
por: Bonsi, Paola, et al.
Publicado: (2018)

Monitoring α-synuclein aggregation
por: Estaun-Panzano, Juan, et al.
Publicado: (2023)

The Emerging Role of Altered d-Aspartate Metabolism in Schizophrenia: New Insights From Preclinical Models and Human Studies
por: Errico, Francesco, et al.
Publicado: (2018)

MicroRNA-101 inhibits the expression of Rhes, a striatal-enriched small G-protein, at the post-transcriptional level in vitro
por: Mizuno, Hideya, et al.
Publicado: (2018)

How Lazy Reading and Semantic Sloppiness May Harm Progress in Synucleinopathy Research
por: Bezard, Erwan
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pjpip0tolele99mh5iole7avln