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Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition
Gamma activity in the subthalamic nucleus (STN) is widely viewed as a pro-kinetic rhythm. Here we test the hypothesis that rather than being specifically linked to movement execution, gamma activity reflects dynamic processing in this nucleus. We investigated the role of gamma during fast stopping a...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526662/ https://www.ncbi.nlm.nih.gov/pubmed/28742498 http://dx.doi.org/10.7554/eLife.23947 |
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author | Fischer, Petra Pogosyan, Alek Herz, Damian M Cheeran, Binith Green, Alexander L Fitzgerald, James Aziz, Tipu Z Hyam, Jonathan Little, Simon Foltynie, Thomas Limousin, Patricia Zrinzo, Ludvic Brown, Peter Tan, Huiling |
author_facet | Fischer, Petra Pogosyan, Alek Herz, Damian M Cheeran, Binith Green, Alexander L Fitzgerald, James Aziz, Tipu Z Hyam, Jonathan Little, Simon Foltynie, Thomas Limousin, Patricia Zrinzo, Ludvic Brown, Peter Tan, Huiling |
author_sort | Fischer, Petra |
collection | PubMed |
description | Gamma activity in the subthalamic nucleus (STN) is widely viewed as a pro-kinetic rhythm. Here we test the hypothesis that rather than being specifically linked to movement execution, gamma activity reflects dynamic processing in this nucleus. We investigated the role of gamma during fast stopping and recorded scalp electroencephalogram and local field potentials from deep brain stimulation electrodes in 9 Parkinson’s disease patients. Patients interrupted finger tapping (paced by a metronome) in response to a stop-signal sound, which was timed such that successful stopping would occur only in ~50% of all trials. STN gamma (60–90 Hz) increased most strongly when the tap was successfully stopped, whereas phase-based connectivity between the contralateral STN and motor cortex decreased. Beta or theta power seemed less directly related to stopping. In summary, STN gamma activity may support flexible motor control as it did not only increase during movement execution but also during rapid action-stopping. DOI: http://dx.doi.org/10.7554/eLife.23947.001 |
format | Online Article Text |
id | pubmed-5526662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55266622017-07-26 Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition Fischer, Petra Pogosyan, Alek Herz, Damian M Cheeran, Binith Green, Alexander L Fitzgerald, James Aziz, Tipu Z Hyam, Jonathan Little, Simon Foltynie, Thomas Limousin, Patricia Zrinzo, Ludvic Brown, Peter Tan, Huiling eLife Neuroscience Gamma activity in the subthalamic nucleus (STN) is widely viewed as a pro-kinetic rhythm. Here we test the hypothesis that rather than being specifically linked to movement execution, gamma activity reflects dynamic processing in this nucleus. We investigated the role of gamma during fast stopping and recorded scalp electroencephalogram and local field potentials from deep brain stimulation electrodes in 9 Parkinson’s disease patients. Patients interrupted finger tapping (paced by a metronome) in response to a stop-signal sound, which was timed such that successful stopping would occur only in ~50% of all trials. STN gamma (60–90 Hz) increased most strongly when the tap was successfully stopped, whereas phase-based connectivity between the contralateral STN and motor cortex decreased. Beta or theta power seemed less directly related to stopping. In summary, STN gamma activity may support flexible motor control as it did not only increase during movement execution but also during rapid action-stopping. DOI: http://dx.doi.org/10.7554/eLife.23947.001 eLife Sciences Publications, Ltd 2017-07-25 /pmc/articles/PMC5526662/ /pubmed/28742498 http://dx.doi.org/10.7554/eLife.23947 Text en © 2017, Fischer et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Fischer, Petra Pogosyan, Alek Herz, Damian M Cheeran, Binith Green, Alexander L Fitzgerald, James Aziz, Tipu Z Hyam, Jonathan Little, Simon Foltynie, Thomas Limousin, Patricia Zrinzo, Ludvic Brown, Peter Tan, Huiling Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition |
title | Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition |
title_full | Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition |
title_fullStr | Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition |
title_full_unstemmed | Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition |
title_short | Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition |
title_sort | subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526662/ https://www.ncbi.nlm.nih.gov/pubmed/28742498 http://dx.doi.org/10.7554/eLife.23947 |
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