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A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout
We have combined a machine-learning approach with other strategies to optimize knockout efficiency with the CRISPR/Cas9 system. In addition, we have developed a multiplexed sgRNA expression strategy that promotes the functional ablation of single genes and allows for combinatorial targeting. These s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526787/ https://www.ncbi.nlm.nih.gov/pubmed/28732207 http://dx.doi.org/10.1016/j.molcel.2017.06.030 |
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