PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response

Mec1(ATR) mediates the DNA damage response (DDR), integrating chromosomal signals and mechanical stimuli. We show that the PP2A phosphatases, ceramide-activated enzymes, couple cell metabolism with the DDR. Using genomic screens, metabolic analysis, and genetic and pharmacological studies, we found...

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Detalles Bibliográficos
Autores principales: Ferrari, Elisa, Bruhn, Christopher, Peretti, Marta, Cassani, Corinne, Carotenuto, Walter Vincenzo, Elgendy, Mohamed, Shubassi, Ghadeer, Lucca, Chiara, Bermejo, Rodrigo, Varasi, Mario, Minucci, Saverio, Longhese, Maria Pia, Foiani, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526790/
https://www.ncbi.nlm.nih.gov/pubmed/28648781
http://dx.doi.org/10.1016/j.molcel.2017.05.027

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