Structure of Chorismate Mutase-like Domain of DAHPS from Bacillus subtilis Complexed with Novel Inhibitor Reveals Conformational Plasticity of Active Site

3-deoxy-D-arabino-heptulosonate-7-phosphate-synthase (DAHPS) is the first enzyme of the shikimate pathway and is responsible for the synthesis of aromatic amino acids in microorganisms. This pathway is an attractive target for antimicrobial drugs. In Bacillus subtilis, the N-terminal domain of the b...

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Detalles Bibliográficos
Autores principales: Pratap, Shivendra, Dev, Aditya, Kumar, Vijay, Yadav, Ravi, Narwal, Manju, Tomar, Shailly, Kumar, Pravindra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526877/
https://www.ncbi.nlm.nih.gov/pubmed/28743924
http://dx.doi.org/10.1038/s41598-017-06578-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526877/
https://www.ncbi.nlm.nih.gov/pubmed/28743924
http://dx.doi.org/10.1038/s41598-017-06578-1

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