Cargando…

Anti-inflammatory and chondroprotective effects of the S-adenosylhomocysteine hydrolase inhibitor 3-Deazaneplanocin A, in human articular chondrocytes

3-Deazaneplanocin A (DZNep) is an inhibitor of S-Adenosyl-L-Homocysteine Hydrolase (SAHH) known to inhibit EZH2, a histone methylase upregulated during osteoarthritis. In this study, we assessed its effects in human articular chondrocytes. Anti-inflammatory effects were assessed by Nitric Oxide (NO)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aury-Landas, Juliette, Bazille, Céline, Allas, Lyess, Bouhout, Sara, Chesneau, Christophe, Leclercq, Sylvain, Boumédiene, Karim, Baugé, Catherine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526903/ https://www.ncbi.nlm.nih.gov/pubmed/28744016 http://dx.doi.org/10.1038/s41598-017-06913-6

Ejemplares similares

Evaluation of the impact of S-adenosylmethionine-dependent methyltransferase inhibitor, 3-deazaneplanocin A, on tissue injury and cognitive function in mice
por: Lhuissier, Eva, et al.
Publicado: (2018)

Co-Treatment with the Epigenetic Drug, 3-Deazaneplanocin A (DZNep) and Cisplatin after DZNep Priming Enhances the Response to Platinum-Based Therapy in Chondrosarcomas
por: Lhuissier, Eva, et al.
Publicado: (2021)

3-Deazaneplanocin A (DZNep), an Inhibitor of the Histone Methyltransferase EZH2, Induces Apoptosis and Reduces Cell Migration in Chondrosarcoma Cells
por: Girard, Nicolas, et al.
Publicado: (2014)

Identification of an easy to use 3D culture model to investigate invasion and anticancer drug response in chondrosarcomas
por: Lhuissier, Eva, et al.
Publicado: (2017)

EZH2 inhibition reduces cartilage loss and functional impairment related to osteoarthritis
por: Allas, Lyess, et al.
Publicado: (2020)

S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice
por: Lee, Hyung-Ok, et al.
Publicado: (2018)

Regulation of homocysteine metabolism by Mycobacterium tuberculosis S-adenosylhomocysteine hydrolase
por: Singhal, Anshika, et al.
Publicado: (2013)

The biochemical profile and dietary management in S-adenosylhomocysteine hydrolase deficiency
por: Huang, Yue, et al.
Publicado: (2022)

Chondroprotective Effect of Kartogenin on CD44-Mediated Functions in Articular Cartilage and Chondrocytes
por: Ono, Yohei, et al.
Publicado: (2014)

Modulation of Skin Inflammatory Response by Active Components of Silymarin
por: Juráňová, Jana, et al.
Publicado: (2018)

Description of Joint Alterations Observed in a Family Carrying p.Asn453Ser COMP Variant: Clinical Phenotypes, In Silico Prediction of Functional Impact on COMP Protein and Stability, and Review of the Literature
por: Rochoux, Quitterie, et al.
Publicado: (2021)

Heterogeneity of chondrosarcomas response to irradiations with X-rays and carbon ions: A comparative study on five cell lines
por: Girard, Nicolas, et al.
Publicado: (2020)

Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency
por: Motzek, Antje, et al.
Publicado: (2016)

Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy
por: Wang, Ying, et al.
Publicado: (2022)

Effects of S-Adenosylhomocysteine Hydrolase Downregulation on Wnt Signaling Pathway in SW480 Cells
por: Pavičić, Ivana, et al.
Publicado: (2023)

Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta
por: Baugé, Catherine, et al.
Publicado: (2011)

H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase
por: Zhou, Jichun, et al.
Publicado: (2015)

Betaine Supplementation Attenuates S-Adenosylhomocysteine Hydrolase-Deficiency-Accelerated Atherosclerosis in Apolipoprotein E-Deficient Mice
por: Dai, Xin, et al.
Publicado: (2022)

Case Report: Advanced Skeletal Muscle Imaging in S-Adenosylhomocysteine Hydrolase Deficiency and Further Insight Into Muscle Pathology
por: Petković Ramadža, Danijela, et al.
Publicado: (2022)

Chondroprotective Effects of Gubitong Recipe via Inhibiting Excessive Mitophagy of Chondrocytes
por: Yu, Xin-bo, et al.
Publicado: (2022)

S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) inhibits lung cancer tumorigenesis by regulating cell plasticity
por: Muñoz-Bernart, Melina, et al.
Publicado: (2023)

Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis
por: You, Yiran, et al.
Publicado: (2023)

Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes
por: Liu, Feng-Cheng, et al.
Publicado: (2010)

Correction: S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) inhibits lung cancer tumorigenesis by regulating cell plasticity
por: Muñoz-Bernart, Melina, et al.
Publicado: (2023)

Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis
por: Csaki, Constanze, et al.
Publicado: (2009)

TOL19-001 reduces inflammation and MMP expression in monolayer cultures of tendon cells
por: Baugé, Catherine, et al.
Publicado: (2015)

Anti-Inflammatory and Chondroprotective Effects of Vanillic Acid and Epimedin C in Human Osteoarthritic Chondrocytes
por: Ziadlou, Reihane, et al.
Publicado: (2020)

Higher S-adenosylhomocysteine and lower ratio of S-adenosylmethionine to S-adenosylhomocysteine were more closely associated with increased risk of subclinical atherosclerosis than homocysteine
por: Xiao, Jinghe, et al.
Publicado: (2022)

An Assessment of the Chondroprotective Effects of Intra-Articular Application of Statin and Tetracycline on Early-Stage Experimental Osteoarthritis
por: Dinc, Mustafa, et al.
Publicado: (2012)

Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis
por: Kwon, Hyuk-Kwon, et al.
Publicado: (2021)

Protein kinase B and extracellular signal-regulated kinase contribute to the chondroprotective effect of morroniside on osteoarthritis chondrocytes
por: Cheng, Liang, et al.
Publicado: (2015)

Alteration of S‐adenosylhomocysteine levels affects lignin biosynthesis in switchgrass
por: Bai, Zetao, et al.
Publicado: (2018)

Hypoxia Differentially Affects Chondrogenic Differentiation of Progenitor Cells from Different Origins
por: Hammad, Mira, et al.
Publicado: (2023)

Deazaneplanocin A Is a Promising Drug to Kill Multiple Myeloma Cells in Their Niche
por: Gaudichon, Jérémie, et al.
Publicado: (2014)

Potassium channels in articular chondrocytes
por: Mobasheri, Ali, et al.
Publicado: (2012)

Co-silencing of tomato S-adenosylhomocysteine hydrolase genes confers increased immunity against Pseudomonas syringae pv. tomato DC3000 and enhanced tolerance to drought stress
por: Li, Xiaohui, et al.
Publicado: (2015)

Epigenetically Reprogramming of Human Embryonic Stem Cells by 3-Deazaneplanocin A and Sodium Butyrate
por: Azghadi, Soheila, et al.
Publicado: (2011)

3-Deazaneplanocin A (DZNep), an Inhibitor of S-Adenosylmethionine-dependent Methyltransferase, Promotes Erythroid Differentiation
por: Fujiwara, Tohru, et al.
Publicado: (2014)

Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion
por: Toubhans, Benoit, et al.
Publicado: (2023)

Eupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes
por: Jeong, Jeong-Hee, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1naag6gklji1srv3pg1rb9aqka