Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation

Endogenous cyclic GMP-AMP (cGAMP) binds and activates STING to induce type I interferons. However, whether cGAMP plays any roles in regulating metabolic homeostasis remains unknown. Here we show that exogenous cGAMP ameliorates obesity-associated metabolic dysregulation and uniquely alters proinflam...

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Detalles Bibliográficos
Autores principales: Guo, Xin, Shu, Chang, Li, Honggui, Pei, Ya, Woo, Shih-Lung, Zheng, Juan, Liu, Mengyang, Xu, Hang, Botchlett, Rachel, Guo, Ting, Cai, Yuli, Gao, Xinsheng, Zhou, Jing, Chen, Lu, Li, Qifu, Xiao, Xiaoqiu, Xie, Linglin, Zhang, Ke K., Ji, Jun-Yuan, Huo, Yuqing, Meng, Fanyin, Alpini, Gianfranco, Li, Pingwei, Wu, Chaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526935/
https://www.ncbi.nlm.nih.gov/pubmed/28743914
http://dx.doi.org/10.1038/s41598-017-05884-y

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