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Granulocyte colony-stimulating factor (GCSF) fused with Fc Domain produced from E. coli is less effective than Polyethylene Glycol-conjugated GCSF

Human granulocyte colony-stimulating factor (GCSF) is a well-known cytokine for neutropenia treatment. However, daily injections are required due to the short circulating half-life of the protein. To overcome this bottleneck, we fused GCSF with the Fc domain of IgG1 at the C terminus (GCSF-Fc) and w...

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Detalles Bibliográficos
Autores principales:	Do, Bich Hang, Kang, Hyo Jeong, Song, Jung-A, Nguyen, Minh Tan, Park, Sangsu, Yoo, Jiwon, Nguyen, Anh Ngoc, Kwon, Grace G., Jang, Jaepyeong, Jang, Mihee, Lee, Sunju, So, Seoungjun, Sim, Seongrak, Lee, Kyung Jin, Osborn, Mark J., Choe, Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526978/ https://www.ncbi.nlm.nih.gov/pubmed/28744022 http://dx.doi.org/10.1038/s41598-017-06726-7

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