Cargando…

Biomarkers and non-invasive tests for gastrointestinal mucositis

Gastrointestinal mucositis is a complex inflammatory reaction of the mucous membranes, a side effect of both chemotherapy and radiotherapy. Currently, assessment scales are used to diagnose mucositis. However, a biomarker which would determine whether there is mucositis and thereby establish the sev...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuiken, N. S. S., Rings, E. H. H. M., Blijlevens, N. M. A., Tissing, Wim J. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527064/
https://www.ncbi.nlm.nih.gov/pubmed/28536886
http://dx.doi.org/10.1007/s00520-017-3752-2
_version_ 1783252909761232896
author Kuiken, N. S. S.
Rings, E. H. H. M.
Blijlevens, N. M. A.
Tissing, Wim J. E.
author_facet Kuiken, N. S. S.
Rings, E. H. H. M.
Blijlevens, N. M. A.
Tissing, Wim J. E.
author_sort Kuiken, N. S. S.
collection PubMed
description Gastrointestinal mucositis is a complex inflammatory reaction of the mucous membranes, a side effect of both chemotherapy and radiotherapy. Currently, assessment scales are used to diagnose mucositis. However, a biomarker which would determine whether there is mucositis and thereby establish the severity objectively would be very useful. This will give the opportunity to evaluate studies, to determine risk factors and incidence, and it will make it possible to compare studies. Moreover, this biomarker might improve clinical management for patients. In this paper, we reviewed studies concerning potential biomarkers in blood samples and fecal samples, and potential tests in breath samples and urine samples. We include biomarkers and tests studied in animal models and/or in clinical trials, and discuss the validity, diagnostic accuracy, and applicability.
format Online
Article
Text
id pubmed-5527064
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-55270642017-08-08 Biomarkers and non-invasive tests for gastrointestinal mucositis Kuiken, N. S. S. Rings, E. H. H. M. Blijlevens, N. M. A. Tissing, Wim J. E. Support Care Cancer Review Article Gastrointestinal mucositis is a complex inflammatory reaction of the mucous membranes, a side effect of both chemotherapy and radiotherapy. Currently, assessment scales are used to diagnose mucositis. However, a biomarker which would determine whether there is mucositis and thereby establish the severity objectively would be very useful. This will give the opportunity to evaluate studies, to determine risk factors and incidence, and it will make it possible to compare studies. Moreover, this biomarker might improve clinical management for patients. In this paper, we reviewed studies concerning potential biomarkers in blood samples and fecal samples, and potential tests in breath samples and urine samples. We include biomarkers and tests studied in animal models and/or in clinical trials, and discuss the validity, diagnostic accuracy, and applicability. Springer Berlin Heidelberg 2017-05-24 2017 /pmc/articles/PMC5527064/ /pubmed/28536886 http://dx.doi.org/10.1007/s00520-017-3752-2 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Kuiken, N. S. S.
Rings, E. H. H. M.
Blijlevens, N. M. A.
Tissing, Wim J. E.
Biomarkers and non-invasive tests for gastrointestinal mucositis
title Biomarkers and non-invasive tests for gastrointestinal mucositis
title_full Biomarkers and non-invasive tests for gastrointestinal mucositis
title_fullStr Biomarkers and non-invasive tests for gastrointestinal mucositis
title_full_unstemmed Biomarkers and non-invasive tests for gastrointestinal mucositis
title_short Biomarkers and non-invasive tests for gastrointestinal mucositis
title_sort biomarkers and non-invasive tests for gastrointestinal mucositis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527064/
https://www.ncbi.nlm.nih.gov/pubmed/28536886
http://dx.doi.org/10.1007/s00520-017-3752-2
work_keys_str_mv AT kuikennss biomarkersandnoninvasivetestsforgastrointestinalmucositis
AT ringsehhm biomarkersandnoninvasivetestsforgastrointestinalmucositis
AT blijlevensnma biomarkersandnoninvasivetestsforgastrointestinalmucositis
AT tissingwimje biomarkersandnoninvasivetestsforgastrointestinalmucositis