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Permeability Barrier and Microstructure of Skin Lipid Membrane Models of Impaired Glucosylceramide Processing

Ceramide (Cer) release from glucosylceramides (GlcCer) is critical for the formation of the skin permeability barrier. Changes in β-glucocerebrosidase (GlcCer’ase) activity lead to diminished Cer, GlcCer accumulation and structural defects in SC lipid lamellae; however, the molecular basis for this...

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Detalles Bibliográficos
Autores principales:	Sochorová, Michaela, Staňková, Klára, Pullmannová, Petra, Kováčik, Andrej, Zbytovská, Jarmila, Vávrová, Kateřina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527096/ https://www.ncbi.nlm.nih.gov/pubmed/28744000 http://dx.doi.org/10.1038/s41598-017-06990-7

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