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Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation

Mutations in the RMRP-gene, encoding the lncRNA component of the RNase MRP complex, are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development. However, it is not clear why mutations in RMRP RNA lead to skeletal d...

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Detalles Bibliográficos
Autores principales:	Steinbusch, Mandy M. F., Caron, Marjolein M. J., Surtel, Don A. M., Friedrich, Franziska, Lausch, Ekkehart, Pruijn, Ger J. M., Verhesen, Wouter, Schroen, Blanche L. M., van Rhijn, Lodewijk W., Zabel, Bernhard, Welting, Tim J. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527100/ https://www.ncbi.nlm.nih.gov/pubmed/28743979 http://dx.doi.org/10.1038/s41598-017-06809-5

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