Hyperoside pre-treatment prevents glomerular basement membrane damage in diabetic nephropathy by inhibiting podocyte heparanase expression

Glomerular basement membrane (GBM) damage plays a pivotal role in pathogenesis of albuminuria in diabetic nephropathy (DN). Heparan sulfate (HS) degradation induced by podocyte heparanase is the major cause of GBM thickening and abnormal perm-selectivity. In the present study, we aimed to examine th...

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Detalles Bibliográficos
Autores principales: An, Xiaofei, Zhang, Lin, Yuan, Yanggang, Wang, Bin, Yao, Qiuming, Li, Ling, Zhang, Jisheng, He, Ming, Zhang, Jinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527129/
https://www.ncbi.nlm.nih.gov/pubmed/28743882
http://dx.doi.org/10.1038/s41598-017-06844-2

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