Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

Altered nuclear shape is a defining feature of cancer cells. The mechanisms underlying nuclear dysmorphia in cancer remain poorly understood. Here we identify PPP1R12A and PPP1CB, two subunits of the myosin phosphatase complex that antagonizes actomyosin contractility, as proteins safeguarding nucle...

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Detalles Bibliográficos
Autores principales: Takaki, Tohru, Montagner, Marco, Serres, Murielle P., Le Berre, Maël, Russell, Matt, Collinson, Lucy, Szuhai, Karoly, Howell, Michael, Boulton, Simon J., Sahai, Erik, Petronczki, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527285/
https://www.ncbi.nlm.nih.gov/pubmed/28737169
http://dx.doi.org/10.1038/ncomms16013

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