Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design

The disaccharide trehalose is critical to the survival of pathogenic fungi in their human host. Trehalose-6-phosphate synthase (Tps1) catalyzes the first step of trehalose biosynthesis in fungi. Here, we report the first structures of eukaryotic Tps1s in complex with substrates or substrate analogue...

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Detalles Bibliográficos
Autores principales: Miao, Yi, Tenor, Jennifer L., Toffaletti, Dena L., Maskarinec, Stacey A., Liu, Jiuyu, Lee, Richard E., Perfect, John R., Brennan, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527307/
https://www.ncbi.nlm.nih.gov/pubmed/28743811
http://dx.doi.org/10.1128/mBio.00643-17

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