Multiregion ultra‐deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer

Intratumor heterogeneity (ITH) contributes to cancer progression and chemoresistance. We sought to comprehensively describe ITH of somatic mutations, copy number, and transcriptomic alterations involving clinically and biologically relevant gene pathways in colorectal cancer (CRC). We performed mult...

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Detalles Bibliográficos
Autores principales: Suzuki, Yuka, Ng, Sarah Boonhsi, Chua, Clarinda, Leow, Wei Qiang, Chng, Jermain, Liu, Shi Yang, Ramnarayanan, Kalpana, Gan, Anna, Ho, Dan Liang, Ten, Rachel, Su, Yan, Lezhava, Alexandar, Lai, Jiunn Herng, Koh, Dennis, Lim, Kiat Hon, Tan, Patrick, Rozen, Steven G., Tan, Iain Beehuat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527459/
https://www.ncbi.nlm.nih.gov/pubmed/28145097
http://dx.doi.org/10.1002/1878-0261.12012

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