Enhanced dependency of KRAS‐mutant colorectal cancer cells on RAD51‐dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae

Activating KRAS mutations drive colorectal cancer tumorigenesis and influence response to anti‐EGFR‐targeted therapy. Despite recent advances in understanding Ras signaling biology and the revolution in therapies for melanoma using BRAF inhibitors, no targeted agents have been effective in KRAS‐muta...

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Detalles Bibliográficos
Autores principales: Kalimutho, Murugan, Bain, Amanda L., Mukherjee, Bipasha, Nag, Purba, Nanayakkara, Devathri M., Harten, Sarah K., Harris, Janelle L., Subramanian, Goutham N., Sinha, Debottam, Shirasawa, Senji, Srihari, Sriganesh, Burma, Sandeep, Khanna, Kum Kum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527460/
https://www.ncbi.nlm.nih.gov/pubmed/28173629
http://dx.doi.org/10.1002/1878-0261.12040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527460/
https://www.ncbi.nlm.nih.gov/pubmed/28173629
http://dx.doi.org/10.1002/1878-0261.12040

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