Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins

The susceptibility of colistin-resistant clinical isolates of Klebsiella pneumoniae to ceragenins and antimicrobial peptides (AMPs) suggests that there is little to no cross-resistance between colistin and ceragenins/AMPs and that lipid A modifications are found in bacteria with modest changes in su...

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Autores principales: Hashemi, Marjan M., Rovig, John, Weber, Scott, Hilton, Brian, Forouzan, Mehdi M., Savage, Paul B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527650/
https://www.ncbi.nlm.nih.gov/pubmed/28584137
http://dx.doi.org/10.1128/AAC.00292-17
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author Hashemi, Marjan M.
Rovig, John
Weber, Scott
Hilton, Brian
Forouzan, Mehdi M.
Savage, Paul B.
author_facet Hashemi, Marjan M.
Rovig, John
Weber, Scott
Hilton, Brian
Forouzan, Mehdi M.
Savage, Paul B.
author_sort Hashemi, Marjan M.
collection PubMed
description The susceptibility of colistin-resistant clinical isolates of Klebsiella pneumoniae to ceragenins and antimicrobial peptides (AMPs) suggests that there is little to no cross-resistance between colistin and ceragenins/AMPs and that lipid A modifications are found in bacteria with modest changes in susceptibility to ceragenins and with high levels of resistance to colistin. These results suggest that there are differences in the resistance mechanisms to colistin and ceragenins/AMPs.
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spelling pubmed-55276502017-08-08 Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins Hashemi, Marjan M. Rovig, John Weber, Scott Hilton, Brian Forouzan, Mehdi M. Savage, Paul B. Antimicrob Agents Chemother Mechanisms of Resistance The susceptibility of colistin-resistant clinical isolates of Klebsiella pneumoniae to ceragenins and antimicrobial peptides (AMPs) suggests that there is little to no cross-resistance between colistin and ceragenins/AMPs and that lipid A modifications are found in bacteria with modest changes in susceptibility to ceragenins and with high levels of resistance to colistin. These results suggest that there are differences in the resistance mechanisms to colistin and ceragenins/AMPs. American Society for Microbiology 2017-07-25 /pmc/articles/PMC5527650/ /pubmed/28584137 http://dx.doi.org/10.1128/AAC.00292-17 Text en Copyright © 2017 Hashemi et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
Hashemi, Marjan M.
Rovig, John
Weber, Scott
Hilton, Brian
Forouzan, Mehdi M.
Savage, Paul B.
Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins
title Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins
title_full Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins
title_fullStr Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins
title_full_unstemmed Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins
title_short Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins
title_sort susceptibility of colistin-resistant, gram-negative bacteria to antimicrobial peptides and ceragenins
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527650/
https://www.ncbi.nlm.nih.gov/pubmed/28584137
http://dx.doi.org/10.1128/AAC.00292-17
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