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Leptocarpus disjunctus prolongs sleeping time and increases nonrapid eye movement sleep with additional anxiolytic capacity
Leptocarpus disjunctus Mast. (Restionaceae) is an edible plant which has indigenous warnings regarding its side effects which can manifest as dizziness. This study investigated hypnotic and anxiolytic properties using several animal models. Anxiolytic activities were evaluated using locomotor determ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527700/ https://www.ncbi.nlm.nih.gov/pubmed/28795023 http://dx.doi.org/10.4103/japtr.JAPTR_185_16 |
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author | Damjuti, Watchara Fuangfoo, Thanes Palanuvej, Chanida Li, Tingli Ruangrungsi, Nijsiri |
author_facet | Damjuti, Watchara Fuangfoo, Thanes Palanuvej, Chanida Li, Tingli Ruangrungsi, Nijsiri |
author_sort | Damjuti, Watchara |
collection | PubMed |
description | Leptocarpus disjunctus Mast. (Restionaceae) is an edible plant which has indigenous warnings regarding its side effects which can manifest as dizziness. This study investigated hypnotic and anxiolytic properties using several animal models. Anxiolytic activities were evaluated using locomotor determination by elevated plus-maze test, open-field test, and rotarod performance test. Hypnotic activities were performed using pentobarbital sodium-induced sleeping time test. Sleep architecture and quality were obtained from sleep–wake analysis and nonrapid eye movement (NREM) delta activity using electroencephalography. An ethanolic extract of L. disjunctus indicated effective potencies for hypnotic test, locomotor activities, and sleep–wake analysis. Ethanolic extract showed a dose relationship with sleeping time for pentobarbital-induced sleeping time test (P < 0.01) and also an antagonistic effect on shortening in sleep time induced by flumazenil. The consort significantly decreased locomotor activities among animals undergoing elevated plus-maze test, open-field test, and rotarod performance test, whereas sleep–wake analysis showed that sleeping time and NREM sleep increased. Ethanolic extract of L. disjunctus was shown to be anxiolytic, with the possibly of benzodiazepine-like hypnotic activity. |
format | Online Article Text |
id | pubmed-5527700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55277002017-08-09 Leptocarpus disjunctus prolongs sleeping time and increases nonrapid eye movement sleep with additional anxiolytic capacity Damjuti, Watchara Fuangfoo, Thanes Palanuvej, Chanida Li, Tingli Ruangrungsi, Nijsiri J Adv Pharm Technol Res Original Article Leptocarpus disjunctus Mast. (Restionaceae) is an edible plant which has indigenous warnings regarding its side effects which can manifest as dizziness. This study investigated hypnotic and anxiolytic properties using several animal models. Anxiolytic activities were evaluated using locomotor determination by elevated plus-maze test, open-field test, and rotarod performance test. Hypnotic activities were performed using pentobarbital sodium-induced sleeping time test. Sleep architecture and quality were obtained from sleep–wake analysis and nonrapid eye movement (NREM) delta activity using electroencephalography. An ethanolic extract of L. disjunctus indicated effective potencies for hypnotic test, locomotor activities, and sleep–wake analysis. Ethanolic extract showed a dose relationship with sleeping time for pentobarbital-induced sleeping time test (P < 0.01) and also an antagonistic effect on shortening in sleep time induced by flumazenil. The consort significantly decreased locomotor activities among animals undergoing elevated plus-maze test, open-field test, and rotarod performance test, whereas sleep–wake analysis showed that sleeping time and NREM sleep increased. Ethanolic extract of L. disjunctus was shown to be anxiolytic, with the possibly of benzodiazepine-like hypnotic activity. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5527700/ /pubmed/28795023 http://dx.doi.org/10.4103/japtr.JAPTR_185_16 Text en Copyright: © 2017 Journal of Advanced Pharmaceutical Technology & Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Damjuti, Watchara Fuangfoo, Thanes Palanuvej, Chanida Li, Tingli Ruangrungsi, Nijsiri Leptocarpus disjunctus prolongs sleeping time and increases nonrapid eye movement sleep with additional anxiolytic capacity |
title | Leptocarpus disjunctus prolongs sleeping time and increases nonrapid eye movement sleep with additional anxiolytic capacity |
title_full | Leptocarpus disjunctus prolongs sleeping time and increases nonrapid eye movement sleep with additional anxiolytic capacity |
title_fullStr | Leptocarpus disjunctus prolongs sleeping time and increases nonrapid eye movement sleep with additional anxiolytic capacity |
title_full_unstemmed | Leptocarpus disjunctus prolongs sleeping time and increases nonrapid eye movement sleep with additional anxiolytic capacity |
title_short | Leptocarpus disjunctus prolongs sleeping time and increases nonrapid eye movement sleep with additional anxiolytic capacity |
title_sort | leptocarpus disjunctus prolongs sleeping time and increases nonrapid eye movement sleep with additional anxiolytic capacity |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527700/ https://www.ncbi.nlm.nih.gov/pubmed/28795023 http://dx.doi.org/10.4103/japtr.JAPTR_185_16 |
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