Propionibacterium acnes and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment

Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward Propionibacterium acnes leads to activation of Th17 axis. Consequently, th...

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Detalles Bibliográficos
Autores principales: Sardana, Kabir, Verma, Gunjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Current Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527720/
https://www.ncbi.nlm.nih.gov/pubmed/28794550
http://dx.doi.org/10.4103/ijd.IJD_483_16
Descripción
Sumario:Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward Propionibacterium acnes leads to activation of Th17 axis. Consequently, the Th17 cytokines (IL-17, IL-1 β, IL-6, and tumor growth factor, in turn, activate the various pathogenic steps in acne. Drugs such as Vitamin D3 and isotretinoin which target the Th17 pathway may offer an additional pathway for their therapeutic response.

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