Propionibacterium acnes and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment

Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward Propionibacterium acnes leads to activation of Th17 axis. Consequently, th...

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Autores principales: Sardana, Kabir, Verma, Gunjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Current Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527720/
https://www.ncbi.nlm.nih.gov/pubmed/28794550
http://dx.doi.org/10.4103/ijd.IJD_483_16
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author Sardana, Kabir
Verma, Gunjan
author_facet Sardana, Kabir
Verma, Gunjan
author_sort Sardana, Kabir
collection PubMed
description Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward Propionibacterium acnes leads to activation of Th17 axis. Consequently, the Th17 cytokines (IL-17, IL-1 β, IL-6, and tumor growth factor, in turn, activate the various pathogenic steps in acne. Drugs such as Vitamin D3 and isotretinoin which target the Th17 pathway may offer an additional pathway for their therapeutic response.
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spelling pubmed-55277202017-08-09 Propionibacterium acnes and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment Sardana, Kabir Verma, Gunjan Indian J Dermatol Current Perspective Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward Propionibacterium acnes leads to activation of Th17 axis. Consequently, the Th17 cytokines (IL-17, IL-1 β, IL-6, and tumor growth factor, in turn, activate the various pathogenic steps in acne. Drugs such as Vitamin D3 and isotretinoin which target the Th17 pathway may offer an additional pathway for their therapeutic response. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5527720/ /pubmed/28794550 http://dx.doi.org/10.4103/ijd.IJD_483_16 Text en Copyright: © 2017 Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Current Perspective
Sardana, Kabir
Verma, Gunjan
Propionibacterium acnes and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment
title Propionibacterium acnes and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment
title_full Propionibacterium acnes and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment
title_fullStr Propionibacterium acnes and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment
title_full_unstemmed Propionibacterium acnes and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment
title_short Propionibacterium acnes and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment
title_sort propionibacterium acnes and the th1/th17 axis, implications in acne pathogenesis and treatment
topic Current Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527720/
https://www.ncbi.nlm.nih.gov/pubmed/28794550
http://dx.doi.org/10.4103/ijd.IJD_483_16
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