Cargando…
MYC‐y mice: From tumour initiation to therapeutic targeting of endogenous MYC
MYC is one of the best‐studied oncogenes in terms of mouse models of malignancy. MYC overexpression has been targeted to several tissues using transgenic constructs, and more recently as mouse models have evolved, conditional systems have been developed to allow the regulation of MYC expression or a...
Autores principales: | Morton, Jennifer P., Sansom, Owen J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528411/ https://www.ncbi.nlm.nih.gov/pubmed/23523308 http://dx.doi.org/10.1016/j.molonc.2013.02.015 |
Ejemplares similares
-
Therapeutic targeting of “undruggable” MYC
por: Llombart, Victor, et al.
Publicado: (2021) -
Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice
por: Jamerson, M H, et al.
Publicado: (2004) -
The Molecular ‘Myc-anisms’ Behind Myc-Driven Tumorigenesis and the Relevant Myc-Directed Therapeutics
por: McAnulty, Jessica, et al.
Publicado: (2020) -
Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo
por: Phesse, T J, et al.
Publicado: (2014) -
HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation
por: Myant, Kevin B, et al.
Publicado: (2016)