Screening and identification of small molecule inhibitors of ErbB2‐induced invasion

ERBB2 amplification and overexpression are strongly associated with invasive cancer with high recurrence and poor prognosis. Enhanced ErbB2 signaling induces cysteine cathepsin B and L expression leading to their higher proteolytic activity (zFRase activity), which is crucial for the invasion of Erb...

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Detalles Bibliográficos
Autores principales: Brix, D.M., Rafn, B., Bundgaard Clemmensen, K., Andersen, S.H., Ambartsumian, N., Jäättelä, M., Kallunki, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528609/
https://www.ncbi.nlm.nih.gov/pubmed/25070180
http://dx.doi.org/10.1016/j.molonc.2014.07.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528609/
https://www.ncbi.nlm.nih.gov/pubmed/25070180
http://dx.doi.org/10.1016/j.molonc.2014.07.004

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