Concomitant inactivation of the p53‐ and pRB‐ functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo

Chemoresistance is the main obstacle to cancer cure. Contrasting studies focusing on single gene mutations, we hypothesize chemoresistance to be due to inactivation of key pathways affecting cellular mechanisms such as apoptosis, senescence, or DNA repair. In support of this hypothesis, we have prev...

Descripción completa

Detalles Bibliográficos
Autores principales: Knappskog, Stian, Berge, Elisabet O., Chrisanthar, Ranjan, Geisler, Stephanie, Staalesen, Vidar, Leirvaag, Beryl, Yndestad, Synnøve, de Faveri, Elise, Karlsen, Bård O., Wedge, David C., Akslen, Lars A., Lilleng, Peer K., Løkkevik, Erik, Lundgren, Steinar, Østenstad, Bjørn, Risberg, Terje, Mjaaland, Ingvild, Aas, Turid, Lønning, Per E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528784/
https://www.ncbi.nlm.nih.gov/pubmed/26004085
http://dx.doi.org/10.1016/j.molonc.2015.04.008

Ejemplares similares

Ejemplares similares