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Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

Many chemotherapeutic drugs are differentially effective from one patient to the next. Understanding the causes of this variability is a critical step towards the development of personalized treatments and improvements to existing medications. Here, we investigate sensitivity to a group of anti-neop...

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Detalles Bibliográficos
Autores principales:	Zdraljevic, Stefan, Strand, Christine, Seidel, Hannah S., Cook, Daniel E., Doench, John G., Andersen, Erik C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529024/ https://www.ncbi.nlm.nih.gov/pubmed/28700616 http://dx.doi.org/10.1371/journal.pgen.1006891

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