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TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma

Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The curren...

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Autores principales: Tian, Feng, Xu, Jian, Xue, Fangxi, Guan, Encui, Xu, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529205/
https://www.ncbi.nlm.nih.gov/pubmed/28546230
http://dx.doi.org/10.1042/BSR20170301
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author Tian, Feng
Xu, Jian
Xue, Fangxi
Guan, Encui
Xu, Xiaoguang
author_facet Tian, Feng
Xu, Jian
Xue, Fangxi
Guan, Encui
Xu, Xiaoguang
author_sort Tian, Feng
collection PubMed
description Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to identify the clinical significance of TINCR in prognosis and malignant progression of hepatocellular carcinoma (HCC). TINCR expression in HCC specimens at various stages of tumorigenesis were measured by quantitative real-time RT PCR (qRT-PCR). The matched para-carcinoma tissues were used as controls. The associations of TINCR with clinicopathological characteristics, disease-free survival (DFS) and overall survival (OS) of patients were further evaluated. Results revealed that high TINCR expression was significantly correlated with tumor size (P=0.005), tumor differentiation status (P=0.017), TNM stage (P=0.010), and vascular invasion (P=0.004). Moreover, Kaplan–Meier analysis demonstrated that TINCR was correlated to both DFS and OS in HCC cohorts. Patients with high TINCR expression tended to have worse prognosis. Multivariate Cox regression analysis indicated that TINCR was an independent poor prognostic indicator for DFS (HR =1.32, 95% CI: 1.00–1.57, P=0.000) and OS (HR =1.57, 95% CI: 1.30–1.86, P=0.004) in HCC. TINCR was demonstrated as a direct target of miR-137 and miR-133a, and was suppressed by miR-137/miR-133a. These results provide the first evidence that the expression of TINCR in HCC may play an oncogenic role in HCC differentiation, invasion, and metastasis. miR-137/miR-133a-TINCR pathway may serve as a promising target for tumor recurrence and prognosis of patients with HCC.
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spelling pubmed-55292052017-09-12 TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma Tian, Feng Xu, Jian Xue, Fangxi Guan, Encui Xu, Xiaoguang Biosci Rep Research Articles Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to identify the clinical significance of TINCR in prognosis and malignant progression of hepatocellular carcinoma (HCC). TINCR expression in HCC specimens at various stages of tumorigenesis were measured by quantitative real-time RT PCR (qRT-PCR). The matched para-carcinoma tissues were used as controls. The associations of TINCR with clinicopathological characteristics, disease-free survival (DFS) and overall survival (OS) of patients were further evaluated. Results revealed that high TINCR expression was significantly correlated with tumor size (P=0.005), tumor differentiation status (P=0.017), TNM stage (P=0.010), and vascular invasion (P=0.004). Moreover, Kaplan–Meier analysis demonstrated that TINCR was correlated to both DFS and OS in HCC cohorts. Patients with high TINCR expression tended to have worse prognosis. Multivariate Cox regression analysis indicated that TINCR was an independent poor prognostic indicator for DFS (HR =1.32, 95% CI: 1.00–1.57, P=0.000) and OS (HR =1.57, 95% CI: 1.30–1.86, P=0.004) in HCC. TINCR was demonstrated as a direct target of miR-137 and miR-133a, and was suppressed by miR-137/miR-133a. These results provide the first evidence that the expression of TINCR in HCC may play an oncogenic role in HCC differentiation, invasion, and metastasis. miR-137/miR-133a-TINCR pathway may serve as a promising target for tumor recurrence and prognosis of patients with HCC. Portland Press Ltd. 2017-07-27 /pmc/articles/PMC5529205/ /pubmed/28546230 http://dx.doi.org/10.1042/BSR20170301 Text en © 2017 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Tian, Feng
Xu, Jian
Xue, Fangxi
Guan, Encui
Xu, Xiaoguang
TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma
title TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma
title_full TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma
title_fullStr TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma
title_full_unstemmed TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma
title_short TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma
title_sort tincr expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529205/
https://www.ncbi.nlm.nih.gov/pubmed/28546230
http://dx.doi.org/10.1042/BSR20170301
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