Primary resistance to EGFR inhibition in glioblastoma is mediated by a TNF-JNK-Axl-ERK signaling axis

Aberrant EGFR signaling is widespread in cancer, making the EGFR an important target for therapy. EGFR gene amplification and mutation are common in glioblastoma (GBM), but EGFR inhibition has not been effective in treating this tumor. Here, we propose that primary resistance to EGFR inhibition in g...

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Detalles Bibliográficos
Autores principales: Guo, Gao, Gong, Ke, Ali, Sonia, Ali, Neha, Shallwani, Shahzad, Hatanpaa, Kimmo J., Pan, Edward, Mickey, Bruce, Burma, Sandeep, Wang, David H., Kesari, Santosh, Sarkaria, Jann N, Zhao, Dawen, Habib, Amyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529219/
https://www.ncbi.nlm.nih.gov/pubmed/28604685
http://dx.doi.org/10.1038/nn.4584

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