An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome

We have successfully used comparative genomics to identify putative regulatory elements within the human genome that contribute to the tissue specific expression of neuropeptides such as galanin and receptors such as CB1. However, a previous inability to rapidly delete these elements from the mouse...

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Detalles Bibliográficos
Autores principales: Hay, Elizabeth Anne, Khalaf, Abdulla Razak, Marini, Pietro, Brown, Andrew, Heath, Karyn, Sheppard, Darrin, MacKenzie, Alasdair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529291/
https://www.ncbi.nlm.nih.gov/pubmed/27866656
http://dx.doi.org/10.1016/j.npep.2016.11.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529291/
https://www.ncbi.nlm.nih.gov/pubmed/27866656
http://dx.doi.org/10.1016/j.npep.2016.11.003

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