Effect of the nanoformulation of siRNA-lipid assemblies on their cellular uptake and immune stimulation

Two lipid-based nanoformulations have been used to date in clinical studies: lipoplexes and lipid nanoparticles (LNPs). In this study, we prepared small interfering RNA (siRNA)-loaded carriers using lipid components of the same composition to form molecular assemblies of differing structures, and ev...

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Detalles Bibliográficos
Autores principales: Kubota, Kohei, Onishi, Kohei, Sawaki, Kazuaki, Li, Tianshu, Mitsuoka, Kaoru, Sato, Takaaki, Takeoka, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529365/
https://www.ncbi.nlm.nih.gov/pubmed/28790820
http://dx.doi.org/10.2147/IJN.S136426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529365/
https://www.ncbi.nlm.nih.gov/pubmed/28790820
http://dx.doi.org/10.2147/IJN.S136426

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