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Effect of the nanoformulation of siRNA-lipid assemblies on their cellular uptake and immune stimulation

Two lipid-based nanoformulations have been used to date in clinical studies: lipoplexes and lipid nanoparticles (LNPs). In this study, we prepared small interfering RNA (siRNA)-loaded carriers using lipid components of the same composition to form molecular assemblies of differing structures, and ev...

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Detalles Bibliográficos
Autores principales:	Kubota, Kohei, Onishi, Kohei, Sawaki, Kazuaki, Li, Tianshu, Mitsuoka, Kaoru, Sato, Takaaki, Takeoka, Shinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529365/ https://www.ncbi.nlm.nih.gov/pubmed/28790820 http://dx.doi.org/10.2147/IJN.S136426

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