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Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress

For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effects of curcumin against acute stress (once/1 day CCl(4) treatment) and...

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Autores principales: Lee, Hwa-Young, Kim, Seung-Wook, Lee, Geum-Hwa, Choi, Min-Kyung, Chung, Han-Wool, Lee, Yong-Chul, Kim, Hyung-Ryong, Kwon, Ho Jeong, Chae, Han-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529367/
https://www.ncbi.nlm.nih.gov/pubmed/28747775
http://dx.doi.org/10.1038/s41598-017-06872-y
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author Lee, Hwa-Young
Kim, Seung-Wook
Lee, Geum-Hwa
Choi, Min-Kyung
Chung, Han-Wool
Lee, Yong-Chul
Kim, Hyung-Ryong
Kwon, Ho Jeong
Chae, Han-Jung
author_facet Lee, Hwa-Young
Kim, Seung-Wook
Lee, Geum-Hwa
Choi, Min-Kyung
Chung, Han-Wool
Lee, Yong-Chul
Kim, Hyung-Ryong
Kwon, Ho Jeong
Chae, Han-Jung
author_sort Lee, Hwa-Young
collection PubMed
description For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effects of curcumin against acute stress (once/1 day CCl(4) treatment) and chronic-stress (every other day/4week CCl(4) treatment). Compared with acute stress, in which the antioxidant system functioned properly and aspartate transaminase (AST) and ROS production increased, chronic stress increased AST, alanine aminotransferase (ALT), hepatic enzymes, and ROS more significantly, and the antioxidant system became impaired. We also found that ER-originated ROS accumulated in the chronic model, another difference between the two conditions. ER stress was induced consistently, and oxidative intra-ER protein folding status, representatively PDI, was impaired, especially in chronic stress. The PDI-associated client protein hepatic apoB accumulated with the PDI-binding status in chronic stress, and curcumin recovered the altered ER folding status, regulating ER stress and the resultant hepatic dyslipidemia. Throughout this study, curcumin and curcumin-rich Curcuma longa L. extract promoted recovery from CCl(4)-induced hepatic toxicity in both stress conditions. For both stress-associated hepatic dyslipidemia, curcumin and Curcuma longa L. extract might be recommendable to recover liver activity.
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spelling pubmed-55293672017-08-02 Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress Lee, Hwa-Young Kim, Seung-Wook Lee, Geum-Hwa Choi, Min-Kyung Chung, Han-Wool Lee, Yong-Chul Kim, Hyung-Ryong Kwon, Ho Jeong Chae, Han-Jung Sci Rep Article For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effects of curcumin against acute stress (once/1 day CCl(4) treatment) and chronic-stress (every other day/4week CCl(4) treatment). Compared with acute stress, in which the antioxidant system functioned properly and aspartate transaminase (AST) and ROS production increased, chronic stress increased AST, alanine aminotransferase (ALT), hepatic enzymes, and ROS more significantly, and the antioxidant system became impaired. We also found that ER-originated ROS accumulated in the chronic model, another difference between the two conditions. ER stress was induced consistently, and oxidative intra-ER protein folding status, representatively PDI, was impaired, especially in chronic stress. The PDI-associated client protein hepatic apoB accumulated with the PDI-binding status in chronic stress, and curcumin recovered the altered ER folding status, regulating ER stress and the resultant hepatic dyslipidemia. Throughout this study, curcumin and curcumin-rich Curcuma longa L. extract promoted recovery from CCl(4)-induced hepatic toxicity in both stress conditions. For both stress-associated hepatic dyslipidemia, curcumin and Curcuma longa L. extract might be recommendable to recover liver activity. Nature Publishing Group UK 2017-07-26 /pmc/articles/PMC5529367/ /pubmed/28747775 http://dx.doi.org/10.1038/s41598-017-06872-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lee, Hwa-Young
Kim, Seung-Wook
Lee, Geum-Hwa
Choi, Min-Kyung
Chung, Han-Wool
Lee, Yong-Chul
Kim, Hyung-Ryong
Kwon, Ho Jeong
Chae, Han-Jung
Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress
title Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress
title_full Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress
title_fullStr Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress
title_full_unstemmed Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress
title_short Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress
title_sort curcumin and curcuma longa l. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and er stress
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529367/
https://www.ncbi.nlm.nih.gov/pubmed/28747775
http://dx.doi.org/10.1038/s41598-017-06872-y
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