Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation

Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects of metabolism, such as insulin resistance, muscle wasting, mitochondrial dysfunction and hyperlactatemia. Nonetheless, the molecular pathogenesis and the relation between...

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Detalles Bibliográficos
Autores principales: Nakazawa, Harumasa, Ikeda, Kazuhiro, Shinozaki, Shohei, Kobayashi, Masayuki, Ikegami, Yuichi, Fu, Ming, Nakamura, Tomoyuki, Yasuhara, Shingo, Yu, Yong-Ming, Martyn, J. A. Jeevendra, Tompkins, Ronald G., Shimokado, Kentaro, Yorozu, Tomoko, Ito, Hideki, Inoue, Satoshi, Kaneki, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529411/
https://www.ncbi.nlm.nih.gov/pubmed/28747716
http://dx.doi.org/10.1038/s41598-017-07011-3

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