PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells

We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proliferation of Foxp3(+) Tregs, but not Foxp3(−) effector T-cells (Teff), when CD4(+) T-cells are co-cultured with GM-CSF derived bone marrow dendritic cells (G-BMDCs). Events downstream of OX40L/OX40 int...

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Detalles Bibliográficos
Autores principales: Alharshawi, Khaled, Marinelarena, Alejandra, Kumar, Prabhakaran, El-Sayed, Osama, Bhattacharya, Palash, Sun, Zuoming, Epstein, Alan L., Maker, Ajay V., Prabhakar, Bellur S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529425/
https://www.ncbi.nlm.nih.gov/pubmed/28747670
http://dx.doi.org/10.1038/s41598-017-05254-8

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